Manikandan Subramanian: We Show That Impaired Macrophage DNase Secretion Drives the Persistence of NETs
Manikandan Subramanian, Group Leader and Deputy Director of Research at the William Harvey Research Institute, Barts and The London School of Medicine, shared a post on LinkedIn:
“Excited to share our latest study in Circulation Research!
We show that impaired macrophage DNase secretion drives the persistence of NETs (neutrophil extracellular traps/DNA webs), impairing dead cell clearance and contributing to atherosclerotic plaque instability.
Our findings highlight new therapeutic avenues to restore inflammation resolution and improve cardiovascular health.”
Title: Macrophage DNases Limit Neutrophil Extracellular Trap–Mediated Defective Efferocytosis in Atherosclerosis
Authors: Umesh Kumar Dhawan, Tanwi Vartak, Hanna Englert, Stefan Russo, Luiz Ricardo C. Vasconcellos, Aarushi Singhal, Rahul Chakraborty, Karran Kiran Bhagat, Ciaran McDonnell, Mary Connolly, Edward Mulkern, Martin O’Donohoe, Mathias Gelderblom, Thomas Renne, Catherine Godson, Eoin Brennan, Manikandan Subramanian
Read the full article here.
Stay updated with Hemostasis Today.
-
Aug 23, 2026, 17:51Gurpreet Kaurr: A Proud Milestone in Haematology and Oncology
-
Aug 23, 2026, 17:33Kathrine Kaspersen: How Voluntary Plasma Donors Helped Transform Denmark’s Plasma Supply
-
Aug 23, 2026, 16:51Sthanu Subramanian: Empagliflozin and a Rise in Hematocrit
-
Aug 23, 2026, 16:50Lale Tokgözoğlu: New PCSK9i Research Published in the European Heart Journal
-
Aug 23, 2026, 16:44Eric Gehrie: Your 2026 Guide to the Essentials of Transfusion Medicine
-
Aug 23, 2026, 16:35Thomas Dayspring: The Overlooked Pathway in Cholesterol Homeostasis
-
Aug 23, 2026, 16:28Evan Mapelu: The People Who Make Cancer Care Meaningful
-
Aug 23, 2026, 16:09Felice Gragnano: New Publication on Aspirin Discontinuation After PCI for Acute Coronary Syndromes
-
Aug 23, 2026, 16:06Mostafa Faisal: Donor Type and Long-Term Quality of Life After HCT for Severe Aplastic Anemia