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Michael Makris: I Believe the Time Has Come to Consider Emicizumab Up Front in Persons with Acquired Hemophilia
Michael Makris/LinkedIn
Nov 27, 2025, 03:47

Michael Makris: I Believe the Time Has Come to Consider Emicizumab Up Front in Persons with Acquired Hemophilia

Michael Makris, Emeritus Professor of Haemostasis and Thrombosis at the University of Sheffield, Editor-in-Chief of RPTH Journal, shared on LinkedIn:

”I believe the time has come to consider emicizumab up front in persons with acquired hemophilia.

I was unsure initially, but all the data is pointing in the right direction.

A German study in the current issue of Blood Advances confirms the value of early emicizumab in acquired hemophilia.

This was not a randomised study, but I feel it will be challenging to do a randomised trial here. The data from Germany, Japan, and the US are consistent.

Emicizumab prevents bleeds whilst immunosuppression is given a chance to work.

The last time I asked, I was told that Roche was not intending to get emicizumab approved in Europe for acquired hemophilia.

If approval and an RCT are not coming, what are we waiting for before considering emicizumab up front in acquired hemophilia?”

Read the full article here.

Article: Sustained survival benefit of emicizumab and postponed immunosuppression in acquired hemophilia A

Authors: Inga M. Schimansky, Christiane Dobbelstein, Robert Klamroth, Christina Hart, Ulrich J. Sachs, Richard Greil, Paul Knöbl, Johannes Oldenburg, Wolfgang Miesbach, Christian Pfrepper, Karolin Trautmann-Grill, Patrick Möhnle, Katharina Holstein, Hermann Eichler, Sonja Werwitzke, Andreas Tiede

Michael Makris: I Believe the Time Has Come to Consider Emicizumab Up Front in Persons with Acquired Hemophilia

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Acquired Hemophilia Andreas Tiede bleeding disorders Blood Advances Christian Pfrepper Christiane Dobbelstein Christina Hart Emicizumab Health Hematology Hemostasis Hemostasis Today Hermann Eichler Inga M. Schimansky Johannes Oldenburg Karolin Trautmann-Grill Katharina Holstein Medicine Michael Makris Patrick Möhnle Paul Knöbl Richard Greil Robert Klamroth Roche Sonja Werwitzke Ulrich J. Sachs Wolfgang Miesbach
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