Michael Makris։ New NEJM Paper Reports Results of Mim8 in Hemophilia A
Michael Makris, Emeritus Professor of Haemostasis and Thrombosis at University of Sheffield, shared a post on LinkedIn about a recent article by Maria Elisa Mancuso et al, published in The New England Journal of Medicine (NEJM), adding։
”The Mim8 results paper was published today in the New England Journal of Medicine.
Mim8 works in the same way and is a direct competitor to emicizumab (Hemlibra).
The introduction of emicizumab has been the most impactful change in hemophilia care in the last 20-25 years.
Both Mim8 and emicizumab are bispecific antibodies. Is one better than the other in terms of efficacy? Only a randomised trial will tell us this, but nobody will do such a trial. I expect there will be lots of papers comparing the two products in a non-randomised way, with all the limitations that they bring.
In most countries, the introduction of a second similar drug will result in competition and lower prices, but I doubt this will be the case in the US.
The PDF of the paper is behind a paywall, but here is the graphical summary.”
Title: Mim8 Bispecific Antibody Prophylaxis in Hemophilia A with or without Inhibitors
Authors: Maria Elisa Mancuso, Anthony K.C. Chan, Chandrakala Shanmukhaiah, Chuhl Joo Lyu, Joanna Zdziarska, Johnny Mahlangu, Lize F.D. van Vulpen, Pratima Chowdary, Renchi Yang, Steven R. Lentz, Tadashi Matsushita, Wan Hui Ong Clausen, Ilgiz Rakhmatullin, Johannes Oldenburg
Other posts featuring Michael Makris on Hemostasis Today.
-
Aug 4, 2026, 02:16New Report Identifies Key Research Priorities for Venous Thrombosis and Stroke – International Journal of Stroke
-
Aug 4, 2026, 02:15Radovan Malý: Finding the Optimal Aspirin Dose in Acute Coronary Syndrome
-
Aug 4, 2026, 02:14Umair Ahmad: Aspirin for Relief Protection and Prevention
-
Aug 4, 2026, 02:12Heavy Menstrual Bleeding in Adolescents Should Never Be Dismissed as “Just a Normal Period” – ICHCC
-
Aug 4, 2026, 02:12Pablo Corral: Viewing Lp(a) as a Multidimensional Particle
-
Aug 3, 2026, 16:01Your First Steps After an ITP Diagnosis – ITP Support Association
-
Aug 3, 2026, 15:33Christina Crossette-Thambiah: Scientific Excellence and Mentorship at ISTH 2026
-
Aug 3, 2026, 15:22Connie Montgomery: Why Global Support is Essential for the HFA Black Voices Initiative
-
Aug 3, 2026, 15:18Ifeanyichukwu Ifechidere: The DOAC Monitoring Masterclass