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Mouna Sassi: Viscoelastic Evidence of Altered Clot Stability in Pediatric Edoxaban Overdose
Mouna Sassi/LinkedIn
Apr 26, 2026, 07:10

Mouna Sassi: Viscoelastic Evidence of Altered Clot Stability in Pediatric Edoxaban Overdose

Mouna Sassi, Head of Laboratory Department at Monastir Maternity Center, Assistant in Hematology at Monastir Hospital–University, shared a post on LinkedIn about a recent article she and her colleagues co-authored, published in TH Open, adding:

“Edoxaban.

Our case confirms that accidental Edoxaban overdose in a healthy child can remain clinically silent with rapid normalization of coagulation tests.

Beyond the benign clinical course, the key finding is the reproducible pattern of increased clot lysis on viscoelastic testing, mimicking FXIII functional impairment despite negligible anti-Xa activity.

This observation suggests a potential indirect effect of edoxaban on clot stabilization at low plasma levels.

Further studies are needed to clarify this mechanism and determine its relevance in pediatric anticoagulation monitoring.”

Title: Edoxaban Overdose in a Child: Unexpected Observation of Clot Lysis

Authors: Mouna Sassi, Emna Sfar, Linda Khefacha, Nouha Berrayana, Radhia Haj Salem, Slaheddine Chouchane

Mouna Sassi: Viscoelastic Evidence of Altered Clot Stability in Pediatric Edoxaban Overdose

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anti-Xa clot edoxaban Emna Sfar Health Hematology Hemostasis News Hemostasis Today Linda Khefacha Medicine Mouna Sassi Nouha Berrayana Radhia Haj Salem Slaheddine Chouchane TH Open
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