Hemostasis Today
NewsFeed
Headlines Hematology Health Medicine VTE ASH Plasma Donation
September, 2026
September 2026
M T W T F S S
 123456
78910111213
14151617181920
21222324252627
282930  
Muhammad Ahsan: Advancing Evidence in Antithrombotic Therapy After STEMI
Muhammad Ahsan/LinkedIn
Sep 7, 2026, 13:20

Muhammad Ahsan: Advancing Evidence in Antithrombotic Therapy After STEMI

Muhammad Ahsan, Medical Student at Ziauddin University, shared a post on LinkedIn about a recent article he and his colleagues co-authored, published in Clinical and Applied Thrombosis/Hemostasis, adding:

“All praise to the Lord of the worlds!

I’m humbled and pleased to share our latest publication in Clinical and Applied Thrombosis/Hemostasis:

‘Triple Antithrombotic Therapy versus Dual Antiplatelet Therapy Alone Following Anterior STEMI: A Systematic Review and Meta-Analysis With GRADE Assessment’. Sage Sage Journals

This project is particularly meaningful to me as I had the opportunity to serve as the first author and lead the study from conceptualization and methodology through data analysis, interpretation, and manuscript preparation.

We synthesized evidence from 7 studies involving 3,692 patients with anterior STEMI undergoing primary PCI, addressing an important clinical question: does adding prophylactic anticoagulation to dual antiplatelet therapy meaningfully reduce the risk of left ventricular thrombus, and does that potential benefit justify the additional bleeding risk?

Our analysis found that triple antithrombotic therapy was associated with more than twice the risk of bleeding (RR 2.10, 95% CI 1.60-2.76), while reductions in left ventricular thrombus and other ischemic outcomes were not statistically significant.

Importantly, several estimates remained imprecise, highlighting the limitations of the current evidence base rather than simply demonstrating ‘no benefit.’

For me, the most valuable part of this project was learning that evidence synthesis is not simply about obtaining a statistically significant result.

It is about understanding study design, assessing risk of bias, evaluating certainty of evidence, and translating uncertainty into clinically meaningful conclusions.

I’m grateful to my co-authors and mentors for their contributions and guidance throughout this project.

Another publication, but more importantly, another step toward becoming a better clinician and researcher.”

Title: Triple Antithrombotic Therapy versus Dual Antiplatelet Therapy Alone Following Anterior STEMI, a Systematic Review and Meta-Analysis With GRADE Assessment

Authors: Muhammad Ahsan, Ammad Uddin, Muhammad Ibrahim Siddique, Abbeha Talib, Muhammad Ahmed, Muhammad Tahir, Abdur Rafay Bilal, Faisal Islam, Tawab Aziz Samandari, Shaheer Bin Shafiq

Muhammad Ahsan

Stay updated with Hemostasis Today.

Abbeha Talib Abdur Rafay Bilal Ammad Uddin Anticoagulation bleeding Cardiology Clinical and Applied Thrombosis/Hemostasis DOACs Dual Antiplatelet Therapy Faisal Islam Health Hematology Hemostasis Hemostasis News Hemostasis Today International Society on Thrombosis and Haemostasis ISTH Medicine Muhammad Ahmed Muhammad Ahsan Muhammad Ibrahim Siddique Muhammad Tahir Sage Journals Shaheer Bin Shafiq STEMI stroke Tawab Aziz Samandari thrombosis triple antithrombotic therapy
NewsFeed