Muhammad Ibrahim on Efficacy and Safety of Extended DOACs Use in VTE
Muhammad Ibrahim, Medical Researcher at Research Council of Pakistan, shared on LinkedIn:
”Excited to co-author this amazing systematic review and meta-analysis entitled: Efficacy and Safety of Direct Oral Anticoagulants for Extended Treatment of Venous Thromboembolism.
Clinical question: Should we continue DOACs long-term after initial VTE treatment?
Analysis of 5,600+ patients from RCTs showed:
83% reduction in VTE recurrence
62% reduction in all-cause mortality
No significant increase in major bleeding
Higher clinically relevant non-major bleeding
Bottom line: In properly selected, low-bleeding-risk patients, extended DOAC therapy provides a clear net clinical benefit for secondary prevention of VTE.
Special thanks to Saad Ahmed Waqas for giving me the opportunity to work on and help lead this project.
Read here.
Congratulations to the co-authors: Muhammad Waqas, Muhammad Ahmed, Maimoona Nasir, Muhammad Khalid Afridi, Gregg C. Fonarow.”
Article: Efficacy and Safety of Direct Oral Anticoagulants for Extended Treatment of Venous Thromboembolism: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Waqas Muhammad, Muhammad Ahmed, Muhammad Ibrahim, Maimoona Nasir, Muhammad Khalid Afridi, Gregg C. Fonarow, Saad Ahmed Waqas
Stay updated on all scientific advances with Hemostasis Today.
-
Jan 25, 2026, 15:57Céline Chapelle Shares Clinical Predictors From the API-CAT Trial
-
Jan 25, 2026, 15:42Francesco Lo Monaco on Heart Disease Starting Quiet While Your Labs Speak First
-
Jan 25, 2026, 15:33Wilfried Dinh: Why Heart Patients Still Have Events Despite ”Optimal” Cardiovascular Therapy
-
Jan 25, 2026, 15:08Tushar Pandey on Managing Thrombotic Thrombocytopenic Purpura
-
Jan 25, 2026, 14:55Carolina Contreras Cuevas Shares a Nationwide Study on VTE in PAD
-
Jan 25, 2026, 14:40Jeannie Devereaux Links PRP and Physical Therapy
-
Jan 25, 2026, 14:25Heghine Khachatryan on Anticoagulation After AFib Ablation: New Evidence from NEJM
-
Jan 25, 2026, 12:42Lale Tokgözoğlu on Cardiovascular Risk Factors in Women
-
Jan 25, 2026, 12:32Dino Mehic on Bleeding Assessment Tools and QoL in BDUC