Olivier Christoph: Where Does Factor VIII Really Come From?
Olivier Christoph, Director of Research at Inserm, shared a post on LinkedIn about a recent article by Paige E. Patterson et al. published in Blood Advances, adding:
“Where does Factor VIII really come from?
After decades of debate, this study led by Radoslaw (Radek) Kaczmarek and Roland W Herzog brings real clarity. Using an elegant gene-edited mouse model together with human tissues, the authors show that FVIII is produced by liver sinusoidal endothelial cells—not hepatocytes.
What really stood out to me is the level of precision: FVIII expression is highly zonal, concentrated in hepatic Zones 2 and 3, and even detectable in renal endothelial cells.
By pinpointing the true cellular and microanatomical sources of FVIII, this work doesn’t just settle a long-standing question—it offers a strong roadmap for designing gene therapies for hemophilia A that better match physiological reality.”
Title: Factor VIII originates primarily from anatomically distinct subsets of liver sinusoidal endothelial cells
Authors: Paige E. Patterson, Audrey Kapelanski-Lamoureux, Cynthia Lebeaupin, Peter Metrakos, Anthoula Lazaris, Wenjun Zhang, Chandrashekhar Avinash Kubal, Renzhi Han, Sreevani Arisa, Oded Danziger, Brad R. Rosenberg, Eleftherios Michailidis, Charles M. Rice, Ype P. de Jong, Randal J Kaufman, Roland W. Herzog, Radoslaw Kaczmarek
Read the Full Article on Blood Advances
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