Hemostasis Today
NewsFeed
Headlines Hematology Health Medicine VTE ASH Plasma Donation
August, 2026
August 2026
M T W T F S S
 12
3456789
10111213141516
17181920212223
24252627282930
31  
Olivier Christoph: Where Does Factor VIII Really Come From?
Olivier D. Christophe/isth; Radoslaw (Radek) Kaczmarek and Roland W Herzog/LinkedIn
Feb 7, 2026, 16:39

Olivier Christoph: Where Does Factor VIII Really Come From?

Olivier Christoph, Director of Research at Inserm, shared a post on LinkedIn about a recent article by Paige E. Patterson et al. published in Blood Advances, adding:

“Where does Factor VIII really come from?

After decades of debate, this study led by Radoslaw (Radek) Kaczmarek and Roland W Herzog brings real clarity. Using an elegant gene-edited mouse model together with human tissues, the authors show that FVIII is produced by liver sinusoidal endothelial cells—not hepatocytes.

What really stood out to me is the level of precision: FVIII expression is highly zonal, concentrated in hepatic Zones 2 and 3, and even detectable in renal endothelial cells.

By pinpointing the true cellular and microanatomical sources of FVIII, this work doesn’t just settle a long-standing question—it offers a strong roadmap for designing gene therapies for hemophilia A that better match physiological reality.”

Title: Factor VIII originates primarily from anatomically distinct subsets of liver sinusoidal endothelial cells

Authors: Paige E. Patterson, Audrey Kapelanski-Lamoureux, Cynthia Lebeaupin, Peter Metrakos, Anthoula Lazaris, Wenjun Zhang, Chandrashekhar Avinash Kubal, Renzhi Han, Sreevani Arisa, Oded Danziger, Brad R. Rosenberg, Eleftherios Michailidis, Charles M. Rice, Ype P. de Jong, Randal J Kaufman, Roland W. Herzog, Radoslaw Kaczmarek

Read the Full Article on Blood Advances

Olivier Christoph: Where Does Factor VIII Really Come From?

 

Stay updated on all scientific advances with Hemostasis Today.

Anthoula Lazaris Audrey Kapelanski-Lamoureux Brad R. Rosenberg Chandrashekhar Avinash Kubal Charles M. Rice Cynthia Lebeaupin Eleftherios Michailidis Factor VIII Headlines Health Hematology Hemophilia A Hemostasis News Hemostasis Today Medicine Oded Danziger Olivier Christoph Paige E. Patterson Peter Metrakos Radoslaw Kaczmarek Randal J Kaufman Renzhi Han Roland W. Herzog Sreevani Arisa Wenjun Zhang Ype P. de Jong
NewsFeed