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Pablo Corral: “The lower, The better” Applies to The Brain Too
Pablo Corral/LinkedIn
Nov 6, 2025, 04:48

Pablo Corral: “The lower, The better” Applies to The Brain Too

Pablo Corral, Pharmacology Professor at FASTA University, Past President of Argentine Lipid Society, posted on LinkedIn:

”Lower LDL-C, Lower Risk – Safely

New analysis from FOURIER & FOURIER-OLE (Monguillon et al., Circulation 2025):

In patients with prior ischemic stroke, achieving LDL-C <40 mg/dL led to a continuous reduction in MACE and recurrent stroke, without any increase in hemorrhagic stroke.

  • 5,291 stroke patients
  • Follow-up up to 7 years
  • Stepwise reduction in cardiovascular and ischemic events with lower LDL-C
  • Hemorrhagic strokes: rare and unrelated to LDL-C

Conclusion: Very low LDL-C levels (<40 mg/dL) are both effective and safe for secondary prevention after stroke – confirming that “the lower, the better” also applies to the brain.”

Read the full article here.

Title: Efficacy and Safety of Very Low Achieved LDL-Cholesterol in Patients with Prior Ischemic Stroke

Authors: Victorien Monguillon, Peter Kelly, Michelle L. O’Donoghue, Jeong-Gun Park, Erin A. Bohula, Jeffrey L. Saver, Dan Atar, Anthony C. Keech, Peter S. Sever, Huei Wang, Gabriel Paiva da Silva Lima, Marc S. Sabatine, Robert P. Giugliano

Cholesterol

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Anthony C. Keech Argentine Lipid Society Dan Atar Erin A. Bohula FASTA University FOURIER & FOURIER-OLE Gabriel Paiva da Silva Lima Health Hematology Hemostasis Hemostasis Today Huei Wang Ischemic stroke Jeffrey L. Saver Jeong-Gun Park LDL Cholesterol Marc S Sabatine Medicine Michelle L O'Donoghue Neurology Pablo Corral Peter Kelly Peter S. Sever recurrent stroke Robert P. Giugliano stroke stroke prevention thrombosis Victorien Monguillon
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