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Rens De Groot: New Proteomic Evidence Reveals Early Hemolysis During ADAMTS13 Relapse in Immune TTP
Rens De Groot/LinkedIn
Jul 11, 2026, 19:19

Rens De Groot: New Proteomic Evidence Reveals Early Hemolysis During ADAMTS13 Relapse in Immune TTP

Rens De Groot, Principal Research Fellow at University College London, shared on LinkedIn about a recent article he and his colleagues co-authored, published in Blood Advances, adding:

”New paper in Blood Advances.

In immune TTP, we found haemolysis is already underway during an ADAMTS13 relapse – while patients are still clinically well and routine markers like platelet count and LDH look normal.

Using unbiased plasma proteomics across 24 iTTP patients, we saw a clear haemolysis signature whenever ADAMTS13 activity was low.

All reversible once ADAMTS13 recovered.

So a low ADAMTS13 isn’t just a risk marker — the pathways that drive acute TTP are already switched on. Should the threshold for pre-emptive rituximab be reconsidered?

Led by Tim Postmus and Pieter Langerhorst, with Maryam Subhan, Eva Smit, Jan Voorberg, Mari Thomas, Maartje van den Biggelaar, and Marie Scully, – a Sanquin / UCL, / University College London Hospitals NHS Foundation Trust collaboration.

Thanks to the UK TTP Registry and the patients who made it possible.”

Title: Unbiased plasma proteomics reveals hemolysis during ADAMTS13 relapse in patients with immune TTP.

Authors: Tim Postmus, Maryam Owais Subhan, Eva R Smit, Jan Voorberg, Mari Thomas, Maartje van den Biggelaar, Marie Scully, Rens de Groot, Pieter Langerhorst

Rens De Groot: New Proteomic Evidence Reveals Early Hemolysis During ADAMTS13 Relapse in Immune TTP

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ADAMTS13 bleeding disorders Blood Advances Eva R Smit Health Hematology Hemostasis Hemostasis News Hemostasis Today iTTP Jan Voorberg Maartje van den Biggelaar Mari Thomas Marie Scully Maryam Owais Subhan Medicine Pieter Langerhorst Rens de Groot Sanquin Tim Postmus UCL University College London Hospitals NHS Foundation Trust
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