Rens De Groot: New Proteomic Evidence Reveals Early Hemolysis During ADAMTS13 Relapse in Immune TTP
Rens De Groot, Principal Research Fellow at University College London, shared on LinkedIn about a recent article he and his colleagues co-authored, published in Blood Advances, adding:
”New paper in Blood Advances.
In immune TTP, we found haemolysis is already underway during an ADAMTS13 relapse – while patients are still clinically well and routine markers like platelet count and LDH look normal.
Using unbiased plasma proteomics across 24 iTTP patients, we saw a clear haemolysis signature whenever ADAMTS13 activity was low.
All reversible once ADAMTS13 recovered.
So a low ADAMTS13 isn’t just a risk marker — the pathways that drive acute TTP are already switched on. Should the threshold for pre-emptive rituximab be reconsidered?
Led by Tim Postmus and Pieter Langerhorst, with Maryam Subhan, Eva Smit, Jan Voorberg, Mari Thomas, Maartje van den Biggelaar, and Marie Scully, – a Sanquin / UCL, / University College London Hospitals NHS Foundation Trust collaboration.
Thanks to the UK TTP Registry and the patients who made it possible.”
Title: Unbiased plasma proteomics reveals hemolysis during ADAMTS13 relapse in patients with immune TTP.
Authors: Tim Postmus, Maryam Owais Subhan, Eva R Smit, Jan Voorberg, Mari Thomas, Maartje van den Biggelaar, Marie Scully, Rens de Groot, Pieter Langerhorst
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