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Rishabh Jain: MPNs May Finally Be Moving from Disease Control to Clonal Eradication
Dr Rishabh Jain/X
Aug 20, 2026, 18:15

Rishabh Jain: MPNs May Finally Be Moving from Disease Control to Clonal Eradication

Rishabh Jain, Medical Oncologist at AIIMS Delhi, shared a post on X about a recent article by Isabelle Plo and William Vainchenker, published in NEJM, adding:

“MPNs may finally be moving from disease control to clonal eradication.

A new NEJM review highlights the biology reshaping treatment of ET, PV and myelofibrosis:

  • More than 90% driven by JAK2, CALR or MPL mutations
  • Driver mutations can arise decades before clinical disease
  • Inflammation fuels clonal dominance, fibrosis and thrombosis
  • Current therapy mainly controls counts, symptoms and thrombosis
  • Next frontier: mutation-selective therapy

Most exciting:

  • INCA033989, anti-mutant CALR antibody: hematologic and molecular responses in more than 90% of refractory or intolerant CALR-mutant ET in early data
  • CALR×CD3 bispecifics and selective JAK2 V617F inhibitors are entering clinical development.

This could mark the shift from managing MPNs to eliminating the malignant clone.”

Title: Myeloproliferative Neoplasms

Authors: Isabelle Plo, William Vainchenker

Rishabh Jain

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Blood CALR clonal eradication ET Health Hematology Hemostasis Hemostasis News Hemostasis Today Isabelle Plo JAK2 Medicine MPL myelofibrosis myeloproliferative neoplasms NEJM PV Rishabh Jain thrombosis William Vainchenker
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