Hemostasis Today
NewsFeed
Headlines Hematology Health Medicine VTE ASH Plasma Donation
August, 2026
August 2026
M T W T F S S
 12
3456789
10111213141516
17181920212223
24252627282930
31  
Rishabh Jain: MPNs May Finally Be Moving from Disease Control to Clonal Eradication
Dr Rishabh Jain/X
Aug 20, 2026, 18:15

Rishabh Jain: MPNs May Finally Be Moving from Disease Control to Clonal Eradication

Rishabh Jain, Medical Oncologist at AIIMS Delhi, shared a post on X about a recent article by Isabelle Plo and William Vainchenker, published in NEJM, adding:

“MPNs may finally be moving from disease control to clonal eradication.

A new NEJM review highlights the biology reshaping treatment of ET, PV and myelofibrosis:

  • More than 90% driven by JAK2, CALR or MPL mutations
  • Driver mutations can arise decades before clinical disease
  • Inflammation fuels clonal dominance, fibrosis and thrombosis
  • Current therapy mainly controls counts, symptoms and thrombosis
  • Next frontier: mutation-selective therapy

Most exciting:

  • INCA033989, anti-mutant CALR antibody: hematologic and molecular responses in more than 90% of refractory or intolerant CALR-mutant ET in early data
  • CALR×CD3 bispecifics and selective JAK2 V617F inhibitors are entering clinical development.

This could mark the shift from managing MPNs to eliminating the malignant clone.”

Title: Myeloproliferative Neoplasms

Authors: Isabelle Plo, William Vainchenker

Rishabh Jain

Stay updated on all scientific advances with Hemostasis Today.

Blood CALR clonal eradication ET Health Hematology Hemostasis Hemostasis News Hemostasis Today Isabelle Plo JAK2 Medicine MPL myelofibrosis myeloproliferative neoplasms NEJM PV Rishabh Jain thrombosis William Vainchenker
NewsFeed