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Sophia Delicou: Iron Chelation Plateaus and Organ-Specific Iron Distribution in β-Thalassemia
Sophia Delicou/LinkedIn
May 18, 2026, 08:04

Sophia Delicou: Iron Chelation Plateaus and Organ-Specific Iron Distribution in β-Thalassemia

Sophia Delicou, Head of Thalassemia and Sickle Cell Unit, Head of the Expertise Center of Hemoglobin Diseases and Their Complications at Hippokrateio General Hospital, shared a post on LinkedIn about a recent article she and her colleagues co-authored, published in Expert Review of Hematology, adding:

“Excited to share our latest publication in Expert Review of Hematology!

In this review, we explore a challenge many clinicians face in transfusion-dependent β-thalassemia: the apparent ‘plateau’ during iron chelation therapy, when ferritin or MRI iron indices stop improving despite ongoing treatment.

A few key points from our work:

  • Many ‘plateaus’ may actually reflect steady-state iron balance rather than treatment failure
  • Ferritin alone can be misleading, especially at high levels
  • Multi-organ MRI (liver, cardiac, pancreatic iron) is essential for understanding iron distribution and treatment response
  • Organ-specific iron compartmentalization may explain why some patients respond differently to different chelation strategies
  • Personalized and organ-targeted approaches are likely the future of iron overload management

Very grateful to all co-authors and collaborators of our  multidisciplinary team for this wonderful teamwork and especially to our patients, who continue to inspire both clinical care and research every single day.”

Title: Apparent plateaus during iron chelation in transfusion-dependent β-thalassemia: interpretation and clinical implications

Authors: Sophia Delicou, Constantina Aggeli, Iliana Mani, Christos Savvidis, Aikaterini Xydaki, Maria Moraki, John Koskinas

Sophia Delicou: Iron Chelation Plateaus and Organ-Specific Iron Distribution in β-Thalassemia

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Aikaterini Xydaki Christos Savvidis Constantina Aggeli Expert Review of Hematology Health Hematology Hemostasis Hemostasis News Hemostasis Today Iliana Mani John Koskinas Maria Moraki Medicine Sophia Delicou Thalassemia
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