Todd Davenport on The Impacts of Long COVID
Todd Davenport, Professor and Chair, Department of Physical Therapy, University of the Pacific, shared on LinkedIn:
”Our latest manuscript, “ME/CFS and Long COVID Demonstrate Similar Bioenergetic Impairment and Recovery Failure on Two‑Day Cardiopulmonary Exercise Testing,” is now posted as a preprint.
Using two‑day cardiopulmonary exercise testing (CPET), we compared physiologic responses in people living with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), Long COVID, and matched non‑disabled controls, stratifying our analysis by sex.
Here’s what we learned:
- Both ME/CFS and Long COVID show similar failure to recover after exertion
- Largest impairments occur at the ventilatory anaerobic threshold, suggesting similar aerobic system impairment
- Females exhibited more pronounced post‑exertional abnormalities than males
- No meaningful differences were observed between ME/CFS and Long COVID on two-day CPET, suggesting they share a bioenergetic pathophysiology
- Severe functional impairment was common in both patient groups and was not explained by effort preference, deconditioning, ventilation, or hemodynamics
These results reinforce post‑exertional malaise (PEM) is a measurable physiological phenomenon.
They underscore the value of two‑day CPET to:
– Differentiate PEM from normal recovery using objective measures
– Inform disability evaluations in people who can and choose to have a CPET
– Improve precision in rehabilitation and treatment trials
I’m grateful to my co‑authors and to the patients.
Their generous engagement continues to advance our understanding of these terribly disabling yet largely ignored chronic conditions.”
Read the full article here.
Article: ME/CFS and Long COVID Demonstrate Similar Bioenergetic Impairment and Recovery Failure on Two-Day Cardiopulmonary Exercise Testing
Authors: Todd Davenport, Staci Stevens, Jared Stevens, Mark Van Ness
Stay updated on all scientific advances with Hemostasis Today.
-
May 7, 2026, 17:56The Latest Clinical Data Shaping The Evolving Landscape of Hemophilia Treatment – EAHAD
-
May 7, 2026, 17:31Talha Badar: New Classical Hematology Chapter on Bleeding and Thrombosis
-
May 7, 2026, 17:26Maria Τektonidou: Gene Network Analysis Identifies STAT1 in Thrombotic APS
-
May 7, 2026, 17:23Sonu Bhaskar: Inflammatory Biomarkers in Acute Cerebral Venous Sinus Thrombosis
-
May 7, 2026, 16:53Patricio S. Espinosa: Anticoagulation Is Not an Absolute Contraindication to Amyloid Therapy
-
May 7, 2026, 16:34Arun V J: Give Blood and Be the Hero You Always Wanted to Be
-
May 7, 2026, 16:15August Bones: When Would You Consider Placing an Inferior Vena Cava Filter After a Pulmonary Embolism?
-
May 7, 2026, 15:58Stop Asking Doctors to Do More – Reimagining the Care Team – The US Oncology
-
May 7, 2026, 15:42Chokri Ben Lamine: CVC-Associated UE-DVT and Catheter Removal