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The Lasting Immunological Footprint of VITT – JTH
First author of the article - Adam Kanack/LinkedIn
Jun 24, 2026, 09:18

The Lasting Immunological Footprint of VITT – JTH

Journal of Thrombosis and Haemostasis (JTH) shared on LinkedIn about a recent article by Adam Kanack et al, adding:

”Platelet factor 4 antibody persistence and long-term pathogenicity in vaccine-induced immune thrombotic thrombocytopenia

In VITT patients, anti-PF4 antibodies persist as monoclonal/oligoclonal clones without epitope spreading, with one case showing platelet-activating antibodies four years post-event.”

Title: Platelet factor 4 antibody persistence and long-term pathogenicity in vaccine-induced immune thrombotic thrombocytopenia

Authors: Adam Kanack, Emily Mauch, Guillaume Roberge, Noah Splinter, Krishna Gundabolu, Geoffrey Wool, Gemlyn George, Mouhamed Yazan Abou-Ismail, Kristi Smock, David Green, Jonathan Coker, Mindy Kohlhagen, David Murray, Anand Padmanabhan

The Lasting Immunological Footprint of VITT - JTH

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Adam Kanack Anand Padmanabhan bleeding disorders David Green David Murray Emily Mauch Gemlyn George Geoffrey Wool Guillaume Roberge Health Hematology Hemostasis Hemostasis News Hemostasis Today immune thrombotic thrombocytopenia Jonathan Coker JTH Krishna Gundabolu Kristi Smock Medicine Mindy Kohlhagen Mouhamed Yazan Abou-Ismail Noah Splinter PF4 Platelet thrombosis VITT
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