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Wolfgang Miesbach on Differential Diagnosis of Thrombocytopenia
Wolfgang Miesbach /LinkedIn
Oct 18, 2025, 16:52

Wolfgang Miesbach on Differential Diagnosis of Thrombocytopenia

Wolfgang Miesbach, Professor of Medicine at Frankfurt University Hospital, shared on LinkedIn:

”Today, our review article on the differential diagnosis of thrombocytopenia was published in the German Medical Journal – a comprehensive overview for clinical practice.

Why is this topic important?
Thrombocytopenia (platelet count < 150,000/µL) is a common coagulation disorder with significant clinical implications.

Approximately 90% of cases can be attributed to immune-mediated diseases, drug-induced forms, pregnancy-associated thrombocytopenia, or infections.

Most common causes:

  • Pregnancy-associated thrombocytopenia
  • Idiopathic thrombocytopenic purpura (ITP)
  • Drug-induced forms (e.g., HIT with unfractionated heparin up to 1%)
  • Infections and systemic diseases

Recognizing critical emergencies:
Life-threatening situations such as thrombotic thrombocytopenic purpura (TTP), heparin-induced thrombocytopenia (HIT), and disseminated intravascular coagulation (DIC) require immediate action.

Structured approach:
The publication offers a practice-oriented diagnostic algorithm that:
– Rules out pseudothrombocytopenia
– Identifies red flags
– Distinguishes between elective and emergency investigations
– Highlights specific treatment options

Take-home message:
Systematic differential diagnosis is crucial for initiating targeted therapies and preventing complications.

The paper offers practical guidance for both general practitioners and specialists.

The complete CME-certified publication is now available in Deutsches Ärzteblatt and offers 3 CME credits.

Many thanks and congratulations to the co-authors!”

Read the full article here.

Article: Differential diagnosis of thrombocytopenia

Authors: Miesbach Wolfgang, Stratmann Jan, Alesci Rosa Sonja, Chromik Jörg, Bakchoul Tamam, Wendt Ralph

Wolfgang Miesbach on Differential Diagnosis of Thrombocytopenia

Stay updated on all scientific advances in the field of platelet disorders with Hemostasis Today.

Alesci Rosa Sonja Bakchoul Tamam bleeding disorders Chromik Jörg DIC German Medical Journal Health Hematology Hemostasis Hemostasis Today HIT Medicine Miesbach Wolfgang Stratmann Jan thrombocytopenia TTP Wendt Ralph
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