Plasma Level Monitoring of DOACs: Balancing Bleeding and Thrombosis Risk
Pall T. Onundarson, Professor Emeritus at Landspitali University Hospital, reposted from Journal of Thrombosis and Haemostasis (JTH) on LinkedIn:
“20 years ago nobody would have been surprised. How else to explain their effect?”
Quoting Journal of Thrombosis and Haemostasis (JTH)’s post on LinkedIn:
“Plasma levels measurement of the 4 direct oral anticoagulants in patients with atrial fibrillation at the time of acute thromboembolic and bleeding events․
This prospective study of 1794 patients with nonvalvular atrial fibrillation found significant interindividual variability in plasma levels of direct oral anticoagulants (DOACs). Low DOAC plasma levels were associated with increased thromboembolic events, while high levels correlated with bleeding events, suggesting plasma level monitoring could help tailor treatment to minimize adverse outcomes.”
Title: Plasma levels measurement of the 4 direct oral anticoagulants in patients with atrial fibrillation at the time of acute thromboembolic and bleeding events
Authors: Cosmo Godino, Riccardo Mazza, Carlo Gaspardone, Alessia Minerva, Rachele Sena, Gianmarco Cozzani, Anna Salerno, Michela Cera, Massimo Slavich, Leila Anna De Lorenzo, Giulio Leo, Giulia Nemola, Annalisa Fattorini, Luciano Crippa, Patrizia Della Valle, Alberto Margonato, Armando D’Angelo
Read the full article here.
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