Hemostasis Today
NewsFeed
Headlines Hematology Health Medicine VTE ASH Plasma Donation
March, 2026
March 2026
M T W T F S S
 1
2345678
9101112131415
16171819202122
23242526272829
3031  
Manikandan Subramanian: We Show That Impaired Macrophage DNase Secretion Drives the Persistence of NETs
Manikandan Subramanian/LinkedIn
Oct 3, 2025, 07:52

Manikandan Subramanian: We Show That Impaired Macrophage DNase Secretion Drives the Persistence of NETs

Manikandan Subramanian, Group Leader and Deputy Director of Research at the William Harvey Research Institute, Barts and The London School of Medicine, shared a post on LinkedIn:

“Excited to share our latest study in Circulation Research!

We show that impaired macrophage DNase secretion drives the persistence of NETs (neutrophil extracellular traps/DNA webs), impairing dead cell clearance and contributing to atherosclerotic plaque instability.

Our findings highlight new therapeutic avenues to restore inflammation resolution and improve cardiovascular health.”

Title: Macrophage DNases Limit Neutrophil Extracellular Trap–Mediated Defective Efferocytosis in Atherosclerosis

Authors: Umesh Kumar Dhawan, Tanwi Vartak, Hanna Englert, Stefan Russo, Luiz Ricardo C. Vasconcellos, Aarushi Singhal, Rahul Chakraborty, Karran Kiran Bhagat, Ciaran McDonnell, Mary Connolly, Edward Mulkern, Martin O’Donohoe, Mathias Gelderblom, Thomas Renne, Catherine Godson, Eoin Brennan, Manikandan Subramanian

Manikandan Subramanian

Read the full article here.

Stay updated with Hemostasis Today.

(inflammation Aarushi Singhal Atherosclerotic Plaque Cardiovascular Health Catherine Godson Ciaran McDonnell Circulation Research Edward Mulkern Eoin Brennan Hanna Englert Health Hematology Hemostasis Hemostasis Today Karran Kiran Bhagat Luiz Ricardo C. Vasconcellos Manikandan Subramanian Martin O’Donohoe Mary Connolly Mathias Gelderblom Medicine NETs Neutrophil Extracellular Traps Rahul Chakraborty Stefan Russo Tanwi Vartak Thomas Renne thrombosis Umesh Kumar Dhawan
NewsFeed