Manikandan Subramanian: We Show That Impaired Macrophage DNase Secretion Drives the Persistence of NETs
Manikandan Subramanian, Group Leader and Deputy Director of Research at the William Harvey Research Institute, Barts and The London School of Medicine, shared a post on LinkedIn:
“Excited to share our latest study in Circulation Research!
We show that impaired macrophage DNase secretion drives the persistence of NETs (neutrophil extracellular traps/DNA webs), impairing dead cell clearance and contributing to atherosclerotic plaque instability.
Our findings highlight new therapeutic avenues to restore inflammation resolution and improve cardiovascular health.”
Title: Macrophage DNases Limit Neutrophil Extracellular Trap–Mediated Defective Efferocytosis in Atherosclerosis
Authors: Umesh Kumar Dhawan, Tanwi Vartak, Hanna Englert, Stefan Russo, Luiz Ricardo C. Vasconcellos, Aarushi Singhal, Rahul Chakraborty, Karran Kiran Bhagat, Ciaran McDonnell, Mary Connolly, Edward Mulkern, Martin O’Donohoe, Mathias Gelderblom, Thomas Renne, Catherine Godson, Eoin Brennan, Manikandan Subramanian
Read the full article here.
Stay updated with Hemostasis Today.
-
Oct 13, 2026, 21:05Francisco Chacón-Lozsán: Heparin-Induced Thrombocytopenia – When an Anticoagulant Triggers Thrombosis
-
Oct 13, 2026, 21:04Aref Zribi: Isolated Tumor Thrombus and the Role of Prophylactic Anticoagulation
-
Oct 13, 2026, 21:01Alex Larson: Why Normal Bloodwork Does Not Always Tell the Whole Story
-
Oct 13, 2026, 20:58Juan Jauregui-Lozano: How Replication Stress Impairs Red Blood Cell Maturation
-
Oct 13, 2026, 20:55Caitlin Raymond: Understanding Platelet Refractoriness Before Ordering More Platelets
-
Oct 13, 2026, 20:54Sanja Seratlic: How Cow Feeding Systems Influence the Anti-Platelet Properties of Cheddar Cheese
-
Oct 13, 2026, 20:50Ruchika Goel: Cord Blood Red Blood Cells as a Physiologically Aligned Transfusion Strategy
-
Oct 13, 2026, 20:47Sophia Delicou: Strengthening Transfusion Safety Through Advanced Screening and Haemovigilance
-
Oct 13, 2026, 20:45Lydia Pecker: Alloimmunization and Transfusion Indications in Sickle Cell Disease Pregnancy