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Steven Murphy Highlights New Research Linking POTS Platelets to Storage Pool Deficiency
Steven AR Murphy MD/LinkedIn
Oct 3, 2025, 16:37

Steven Murphy Highlights New Research Linking POTS Platelets to Storage Pool Deficiency

Steven Murphy, Medical Director, Concierge Medical Associates, shared a post on LinkedIn:

“Are POTS patients’ platelets different? Should we be avoiding PRP in them?

What about in patients with Long COVID and POTS?

An interesting research article was published

“Postural orthostatic tachycardia syndrome in post-COVID-19 long-hauler patients is associated with platelet storage pool deficiency”

Title: Postural orthostatic tachycardia syndrome in post-COVID-19 long-hauler patients is associated with platelet storage pool deficiency

Authors: William T. Gunning III, Saira Khan, John W. Spatafore, Beverly L. Karabin, Blair P. Grubb

Steven Murphy Highlights New Research Linking POTS Platelets to Storage Pool Deficiency

Read more here.

Both POTS groups have δ-SPD, AKA dense (delta) granule storage pool deficiency. There also is a genetic version, but this was not assessed in this study.

PRP has 7 fundamental proteins: platelet derived growth factors (PDGF), transforming growth factor–β (TGF-β), vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), and adhesive proteins – fibrin, fibronectin, and vitronectin…. we think these are the main factors in the success of it.

But my main man Peter A. Everts, PhD, FRSM reviews even more factors.

Title: Platelet-Rich Plasma: New Performance Understandings and Therapeutic Considerations in 2020

Authors: Peter Everts, Kentaro Onishi, Prathap Jayaram, José Fábio Lana, Kenneth Mautner

Steven Murphy Highlights New Research Linking POTS Platelets to Storage Pool Deficiency

Read more here

Dense granules effect platelet activation and Alpha granules contain good stuff. I also add, mitochondria can travel between cells and I posit also help healing in the injured tissue.

But the problem I have is this: Both scenarios above point to platelets that are not “normal”: in long COVID POTS they may be chronically activated/exhausted, and in regular POTS they have intrinsic granule deficits. These features overlap with the concept of platelet senescence or aging. As platelets age (or undergo repeated activation), they lose granule content and responsiveness while gaining pro-inflammatory behavior.

A 2025 review on platelet aging notes that senescent platelets display reduced granule content, impaired responsiveness, and heightened pro-inflammatory factor release, all of which can compromise tissue repair processes.

So I ask all OBX brothers and sisters, what do you do with your POTS or Long COVID POTS patients?

I will be investigating this on my substack next week”

Steven Murphy Highlights New Research Linking POTS Platelets to Storage Pool Deficiency

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Beverly L. Karabin Blair P. Grubb Covid-19 Health Hematology Hemostasis Hemostasis Today John W. Spatafore José Fábio Lana Kenneth Mautner Kentaro Onishi Long COVID Medicine Peter Everts POTS Patients' Platelets Prathap Jayaram Saira Khan Storage Pool Deficiency William T. Gunning III
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