Wolfgang Miesbach on Differential Diagnosis of Thrombocytopenia
Wolfgang Miesbach, Professor of Medicine at Frankfurt University Hospital, shared on LinkedIn:
”Today, our review article on the differential diagnosis of thrombocytopenia was published in the German Medical Journal – a comprehensive overview for clinical practice.
Why is this topic important?
Thrombocytopenia (platelet count < 150,000/µL) is a common coagulation disorder with significant clinical implications.
Approximately 90% of cases can be attributed to immune-mediated diseases, drug-induced forms, pregnancy-associated thrombocytopenia, or infections.
Most common causes:
- Pregnancy-associated thrombocytopenia
- Idiopathic thrombocytopenic purpura (ITP)
- Drug-induced forms (e.g., HIT with unfractionated heparin up to 1%)
- Infections and systemic diseases
Recognizing critical emergencies:
Life-threatening situations such as thrombotic thrombocytopenic purpura (TTP), heparin-induced thrombocytopenia (HIT), and disseminated intravascular coagulation (DIC) require immediate action.
Structured approach:
The publication offers a practice-oriented diagnostic algorithm that:
– Rules out pseudothrombocytopenia
– Identifies red flags
– Distinguishes between elective and emergency investigations
– Highlights specific treatment options
Take-home message:
Systematic differential diagnosis is crucial for initiating targeted therapies and preventing complications.
The paper offers practical guidance for both general practitioners and specialists.
The complete CME-certified publication is now available in Deutsches Ärzteblatt and offers 3 CME credits.
Many thanks and congratulations to the co-authors!”
Read the full article here.
Article: Differential diagnosis of thrombocytopenia
Authors: Miesbach Wolfgang, Stratmann Jan, Alesci Rosa Sonja, Chromik Jörg, Bakchoul Tamam, Wendt Ralph
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