Fabrice Cognasse: When Platelets Meet Artificial Intelligence!
Fabrice Cognasse, Director of Research – Scientific Director at The EFS in Auvergne-Rhône-Alpes and INSERM, shared on LinkedIn:
”New Publication – When Platelets Meet Artificial Intelligence!
I’m pleased to announce the publication of our latest article:
“Computational modeling of platelet activation signatures in response to diverse immune and hemostatic agonists”, now available in Platelets Journal (DOI: 10.1080/09537104.2025.2572982).
This study, a collaboration between SAnté INgéniérie BIOlogie St-Etienne (SAINBIOSE) (INSERM U1059 – Université Jean Monnet Saint-Etienne / École des Mines de Saint-Étienne), EFS Auvergne-Rhône-Alpes, and AltraBio (Lyon), introduces a computational model of platelet activation signatures using machine learning to identify stimulus-specific pathways triggered by immune and hemostatic agonists.
The work is supported by a recently filed patent (WO2021224236A1), combining experimental biology, mathematical modeling, and artificial intelligence to decipher the remarkable plasticity of platelets in thromboinflammatory contexts.
Congratulations to all my amazing co-authors —
Kim-Anh Nguyen-Peyre, Marco Heestermans, Charles Antoine Arthaud, Marie-Ange Eyraud, Amélie Prier, Simon de Bernard, Julien Nourikyan, Anne-Claire Duchez, Stéphane Avril, Olivier Garraud, Hind Hamzeh-Cognasse — for their dedication, teamwork, and scientific insight.
Special thanks to our funding partners: ANR, the French National Research Agency 22-CE17-0063 HEASY-PLAT), EFS, and the Les Amis de Rémi Association, for their continuous support.
This study exemplifies how computational modeling and data-driven biology can advance our understanding of platelet heterogeneity and open new perspectives for diagnosis and therapy in inflammation and thrombosis.”
Read the full article here.
Article: Computational modeling of platelet activation signatures in response to diverse immune and hemostatic agonists
Authors: Fabrice Cognasse, Kim Anh Nguyen, Marco Heestermans, Charles-Antoine Arthaud, Marie-Ange Eyraud, Amelie Prier, Simon de Bernard, Julien Nourikyan, Anne-Claire Duchez, Stephane Avril, Olivier Garraud, Hind Hamzeh-Cognasse
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