Aortic Plaques are More Thrombogenic Than Carotid and Femoral Plaques
Atherosclerosis posted on LinkedIn:
”Not all plaques are born equal
This study compared atherosclerotic plaques from the aorta, carotid, and femoral arteries – revealing striking differences in their thrombogenic potential.
Aortic plaques triggered stronger platelet activation, more thrombin generation, and even occlusive thrombus formation under high shear flow.
The reason? More fibrillar collagen (types I and III) – the perfect substrate for clot formation.
In short: aortic plaques are the most dangerous, not just by location, but by biology.
Should future therapies target plaque composition rather than just plaque size?”
Rea the full article here.
Title: Aortic atherosclerotic plaques are more thrombogenic than carotid and femoral plaques: the role of fibrillar collagen
Authors: Miao Fenga, Andréa Thevenota, Salomé Kuntzb, Chu Liua, Célia Schellenberga, Lise Charlea, Nathalie Brouarda, Christine Schaefferc, Sarahi Jaramillo Ortizc, Judith M.E.M. Cosemansd, Nabil Chakféb, Pierre H. Mangin
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