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Real-World Data from Italy: Luspatercept Shows Promise in Transfusion-Dependent Beta-Thalassemia
Jul 4, 2025, 16:23

Real-World Data from Italy: Luspatercept Shows Promise in Transfusion-Dependent Beta-Thalassemia

Mostafa Faisal, associate professor of Adult Hematology and BMT, recently shared a post on use of Luspatercept on X:

Luspatercept for Transfusion-Dependent Beta-Thalassemia: Real-World Experience in a Large Cohort of Patients From Italy – The American Journal of Hematology.”

Read the full article here.

Following the approval of the drug in the U.S. and Europe—based on the findings of the randomized, placebo-controlled phase III BELIEVE trial—there remained a need to generate robust real-world evidence on its effectiveness, safety, and tolerability in routine clinical settings.

To address this, the impact of luspatercept treatment in a cohort of 231 individuals with TDT was assessed.

Published in the American Journal of Hematology, this new study presents one of the largest real-world cohorts examining the use of the drug in patients with transfusion-dependent beta-thalassemia (TDT) across Italy.

 

Real-World Data from Italy: Luspatercept Shows Promise in Transfusion-Dependent Beta-Thalassemia

To learn more on new scientific advances in hematology, read Hemostasis Today.