William Aird/X
Jul 7, 2025, 11:42
What Drives Essential Thrombocythemia? Dr. William Aird on the Pathophysiology of Platelet Overproduction
Dr. William Aird, Professor of Medicine at Harvard Medical School, has posted on X:
“Essential Thrombocythemia (ET) Pathophysiology
ET is driven by one of 3 mutations:
- JAK2 V617F → cytokine-independent signaling
- CALR → abnormal MPL activation
- MPL → constitutive TPO receptor signaling
All lead to unchecked megakaryocyte proliferation and ↑ platelets.”
Curious about what drives Essential Thrombocythemia? Here’s a quick look at the mutations involved.
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