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What Drives Essential Thrombocythemia? Dr. William Aird on the Pathophysiology of Platelet Overproduction
William Aird/X
Jul 7, 2025, 11:42

What Drives Essential Thrombocythemia? Dr. William Aird on the Pathophysiology of Platelet Overproduction

 Dr. William Aird, Professor of Medicine at Harvard Medical School, has posted on X: 

“Essential Thrombocythemia (ET) Pathophysiology

ET is driven by one of 3 mutations:

  •  JAK2 V617F → cytokine-independent signaling
  •  CALR → abnormal MPL activation
  •  MPL → constitutive TPO receptor signaling

All lead to unchecked megakaryocyte proliferation and ↑ platelets.”

William Aird

Curious about what drives Essential Thrombocythemia? Here’s a quick look at the mutations involved.

Explore more on Hemostasis Today.

Essential Thrombocythemia Harvard Medical School Hematology Hemostasis Hemostasis Today JAK2 V617F platelets William Aird
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