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Heghine Khachatryan: Lupus Anticoagulant – An Old Concept Revisited with New Mechanistic Insight
Heghine Khachatryan/Linkedin
Dec 22, 2025, 07:17

Heghine Khachatryan: Lupus Anticoagulant – An Old Concept Revisited with New Mechanistic Insight

Heghine Khachatryan, Editor-in-Chief of Hemostasis Today, Head of Hemophilia and Thrombosis Center at Yeolyan Hematology and Oncology Center, reposted from Nicola Pozzi on LinkedIn:

“Lupus anticoagulant: an old concept revisited with new mechanistic insight

Recent reflections by Nicola Pozzi remind us that some of the most established concepts in hemostasis and thrombosis still warrant critical re-examination.

In collaboration with Vittorio Pengo, this work revisits lupus anticoagulant from both a historical and mechanistic perspective, integrating emerging insights on antiprothrombin antibodies that have accumulated over recent years.

Why this matters
• Lupus anticoagulant remains a cornerstone laboratory criterion in the diagnosis of antiphospholipid syndrome
• Current testing strategies do not always reflect the underlying biological mechanisms
• New mechanistic data challenge how we interpret and even define what we measure in routine coagulation assays

-This raises an important question:
Is it time to reconsider—and potentially rewrite—parts of our coagulation textbooks?

Progress in science is driven by precisely these moments, when well-established paradigms are revisited in light of robust experimental evidence. Understanding what we measure, why we measure it, and what it truly represents biologically is essential for advancing both diagnostics and patient care.

-Lupus anticoagulant and antiprothrombin antibodies: embracing the future
Journal of Thrombosis and Haemostasis”

Quoting Nicola Pozzi‘s post:

“Hematologists and coagulation enthusiasts—this one’s for you!

Lupus anticoagulant: What is it? How do we measure it? Why does it matter for Antiphospholipid Syndrome (APS)?

Vittorio Pengo and I revisit this highly debated topic with a historical perspective, and share novel mechanistic insights we uncovered in recent years that could reshape how we understand and test for lupus anticoagulant.

Could it be time to rewrite the coagulation textbook? Time (and good science) will tell…”

Title: Lupus anticoagulant and antiprothrombin antibodies: embracing the future

Authors: Vittorio Pengo, Nicola Pozzi

Heghine Khachatryan: Lupus Anticoagulant - An Old Concept Revisited with New Mechanistic Insight

Read also: Danny Hsu and Nicola Pozzi on “Tetra-Positive” APS

Antiphospholipid Syndrome (APS) Heghine Khachatryan Hemostasis Journal of Thrombosis and Haemostasis Lupus Anticoagulant Nicola Pozzi thrombosis Vittorio Pengo
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