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Claudio Laudani on Comparison of Target and Non-target Vessel Revascularization for Recurrent ACS
Claudio Laudani/LinkedIn
Dec 24, 2025, 02:18

Claudio Laudani on Comparison of Target and Non-target Vessel Revascularization for Recurrent ACS

Claudio Laudani, Cardiovascular Disease Fellow UNICT, Post-Doc Research Scholar UFHealth JAX, shared on LinkedIn:

”Patients undergoing repeat revascularization for recurrent acute coronary syndrome represent a particularly high-risk population, yet limited data exist on whether outcomes differ between target-vessel and non-target-vessel revascularization.

In our latest study from the CAST Registry, published in Journal of Cardiovascular Medicine, we analyzed 299 patients undergoing repeat PCI for ACS, and compared the long-term outcomes of patients undergoing TVR vs. non-TVR.

Alos, we explored the predictors of long-term adverse events in this high-risk population.

In our study, we found that:

  • Patients undergoing repeat PCI for ACS represent a very high risk population, with most of the patients presenting with not at target LDL levels.
  • This high thrombotic risk is also reflected in the follow-up event rate, as MACE rates were as high as 37% at 3 years.
  • There were no significant differences between TVR and non-TVR, suggesting that recurrent ischemia is the reflection of a systematic high thrombotic burden phenotype rather than local procedure failure.
  • Variables of procedural complexity were the main predictors of long-term events, including cardiogenic shock at presentation, longer fluoroscopy time, and LAD involvement.

Overall, our data highlight that patients undergoing repeat PCI require a more aggressive treatment to prevent long-term adverse events.”

Read the full article here.

Article: Long-term outcomes of percutaneous coronary intervention for recurrent events in patients undergoing target-vessel vs. nontarget-vessel revascularization

Authors: Simone Finocchiaro, Maria Sara Mauro, Claudio Laudani, Davide Landolina, Placido Maria Mazzone, Antonino Imbesi, Marco Spagnolo, Antonio Greco, Francesco Nasisi, Davide Capodanno

Claudio Laudani on Comparison of Target and Non-target Vessel Revascularization for Recurrent ACS

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ACS Antonino Imbesi Antonio Greco Claudio Laudani Davide Capodanno Davide Landolina Francesco Nasisi Health Hematology Hemostasis Hemostasis Today Journal of Cardiovascular Medicine Marco Spagnolo Maria Sara Mauro Medicine non-TVR PCI Placido Maria Mazzone Simone Finocchiaro thrombosis TVR
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