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Balqees M Al Rafayah: What is Hemophilia?

Balqees M Al Rafayah/LinkedIn

Dec 29, 2025, 07:07

Balqees M Al Rafayah: What is Hemophilia?

Balqees M Al Rafayah, Lab supervisor at Mutah University, shared on LinkedIn:

”What is hemophilia?
• A hereditary bleeding disorder in which the blood does not clot properly due to a deficiency of one of the clotting factors.
• It is inherited either as a sex-linked (X-linked) recessive trait — more common in males while females are carriers — or as an autosomal recessive disorder in the case of Hemophilia C.

– How many types of hemophilia are there and what are they?
There are three main types of hemophilia: Hemophilia A, Hemophilia B, and Hemophilia C.

Each type is caused by a deficiency in a specific clotting factor.

Hemophilia A:
• Also known as classical hemophilia.
• It is the most common hereditary clotting factor deficiency.
• Caused by an X-linked recessive mutation.
• Results from a deficiency in clotting factor VIII.
• Symptoms may include:
– Joint and soft tissue bleeding
– Spontaneous hematuria
– Excessive bruising

Hemophilia B:
• Also known as Christmas disease.
• Caused by an X-linked recessive mutation.
• Results from a deficiency in clotting factor IX.
• Symptoms are similar to Hemophilia A:
– Joint and soft tissue bleeding
– Spontaneous hematuria
– Excessive bruising

Hemophilia C:
• A rare form of hemophilia.
• Inherited as an autosomal recessive disorder.
• Caused by a deficiency in clotting factor XI.
• Usually results in milder symptoms, such as:
– Nosebleeds
– Easy bruising”

Balqees M Al Rafayah: What is Hemophilia?