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Jim Hoffman: Affinity-Based Blood Purification as a Potential Alternative to Plasma Exchange
Jim Hoffman/LinkedIn
Feb 9, 2026, 17:41

Jim Hoffman: Affinity-Based Blood Purification as a Potential Alternative to Plasma Exchange

Jim Hoffman, Former Technical Advisor at Cygnus Technologies, LLC, posted on LinkedIn:

“A business model  for improved therapeutic extracorporeal blood purification methods to follow that are capable of depleting toxic levels of extracellular chromatin from the blood.

These newer affinity-based methods , which effectively deplete extracellular chromatin and allow patients to keep their own blood with greatly reduced toxic levels of extracellular chromatin, should be evaluated as a replacement for more expensive and likely less effective Therapeutic Plasma Exchange (TPE).

This could greatly increase badly needed affordable access to treatment and potentially prevent and treat chronic illness disease progression more efficaciously than TPE.

A small sampling of the research implicating elevated extracellular chromatin contributing to multi-organ injury and disease progression:”

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