Shiny K. Kajal/LinkedIn
Feb 22, 2026, 09:22
Shiny K. Kajal: Not All Transfusion Reactions Are Immunohematologic Incompatibilities
Shiny K. Kajal, Senior Resident at Adesh University, shared a post on LinkedIn:
“Washed PRBCs – Precision Beyond Compatibility
Not all transfusion reactions are immunohematologic incompatibilities.
Sometimes, the culprit is residual plasma.
Washed PRBCs are red cell units processed to remove:
- Plasma proteins
- IgA
- Cytokines
- Bioactive mediators
Indicated in:
- Severe IgA deficiency with anti-IgA
- Recurrent severe allergic transfusion reactions
- Selected neonatal exchange transfusions
Limitations:
- 24-hour shelf life (post-processing)
- RBC loss during washing
- Increased cost and labor
Clinical Insight: Washed red cells are not about matching better —they are about transfusing less of what should not be there.”
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