Bartosz Hudzik: Do Elevated Lipoprotein(a) Levels Predict Long-Term Cardiovascular Risk in Otherwise Healthy Women?
Bartosz Hudzik, Associate Profesor at Medical University of Silesia, shared a post on LinkedIn about a recent article by Ask Tybjærg Nordestgaard et al, adding:
“Do elevated lipoprotein(a) levels predict long-term cardiovascular risk in otherwise healthy women?
A major prospective cohort study of 27,748 women followed for nearly 30 years provides important clarity:
- Lipoprotein(a) >30 mg/dL (≈75th percentile) was linked to higher risk of major cardiovascular events and coronary heart disease.
- Only very high levels (>120 mg/dL, ≈99th percentile) were associated with increased risk of ischemic stroke and cardiovascular death.
- Genetic carriers of the LPA rs3798220 variant also showed higher cardiovascular risk.
The takeaway:
- Very high lipoprotein(a) appears to be a meaningful long-term risk marker even among healthy women, strengthening the case for broader population screening strategies and earlier preventive intervention.
As precision prevention becomes central to cardiology, should Lp(a) testing become routine in midlife risk assessment?
Tagging colleagues advancing prevention science and lipid research.”
Title: Thirty-Year Risk of Cardiovascular Disease Among Healthy Women According to Clinical Thresholds of Lipoprotein(a)
Authors: Ask Tybjærg Nordestgaard, Daniel Chasman, Vinayaga Moorthy, Jordan Kraaijenhof, Nancy Cook, I-Min Lee, Julie Buring, Paul Ridker
Read the Full Article on JAMA Cardiology
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