Wolfgang Miesbach: Targeted Anti-TFPI Therapy with Marstacimab Supports Joint Stability in Hemophilia A
Wolfgang Miesbach, Professor of Medicine at Frankfurt University Hospital, shared a post on LinkedIn:
”Michael Sigl-Kraetzig and colleagues presented at GTH 2026 in Bonn the first European real-world experience with Marstacimab in a patient with haemophilia A and advanced haemophilic arthropathy.
The poster describes a switch from intravenous factor prophylaxis to subcutaneous anti-TFPI prophylaxis (Marstacimab) in a patient with poor prior adherence, resulting in a lower treatment burden and markedly improved adherence.
Joint status was monitored clinically and by standardised ultrasound (HEAD-US), enabling structured assessment of arthropathy progression.
Following a post-traumatic bleed, treatment was escalated to a doubled Marstacimab dose, with ongoing excellent adherence and no thromboembolic events reported so far.
This case highlights how targeted anti-TFPI therapy, combined with standardised imaging and individualised dose adjustment, may support adherence and help stabilise joint outcomes in haemophilia care.”
Stay updated with Hemostasis Today.
-
Apr 22, 2026, 17:19Ralf Ludwig: Bridging Population Data and Immunology in Inflammatory Diseases
-
Apr 22, 2026, 17:15Giacomo Rossi: Genetic Study Reveals 10 Genes in Hyperemesis Gravidarum
-
Apr 22, 2026, 17:06Maura Boerio: Quantifying Barriers to Care in Vascular Ehlers-Danlos Syndrome
-
Apr 22, 2026, 17:05Kausik Ray։ Metabolically Healthy Obesity Is Being Re-Evaluated as a High-Risk Condition Needing Closer Attention
-
Apr 22, 2026, 16:58Baba-Jallah Epega: Sickle Cell Resilience Through Patient Voices and Clinical Insight
-
Apr 22, 2026, 16:44Francisco Chacón-Lozsán: Cytokine Storm Is Not Just Inflammation, It Is Organ Failure in Motion
-
Apr 22, 2026, 16:29CBTH 2026 Opens with First Workshop in Germany – European Hematology Association
-
Apr 22, 2026, 16:16Christopher Pittman: Superficial Venous Disease Needs Arterial-Level Follow-Up
-
Apr 22, 2026, 15:47Mohammed Alo: Being Fit Does Not Protect You from High LDL