Wolfgang Miesbach: Targeted Anti-TFPI Therapy with Marstacimab Supports Joint Stability in Hemophilia A
Wolfgang Miesbach, Professor of Medicine at Frankfurt University Hospital, shared a post on LinkedIn:
”Michael Sigl-Kraetzig and colleagues presented at GTH 2026 in Bonn the first European real-world experience with Marstacimab in a patient with haemophilia A and advanced haemophilic arthropathy.
The poster describes a switch from intravenous factor prophylaxis to subcutaneous anti-TFPI prophylaxis (Marstacimab) in a patient with poor prior adherence, resulting in a lower treatment burden and markedly improved adherence.
Joint status was monitored clinically and by standardised ultrasound (HEAD-US), enabling structured assessment of arthropathy progression.
Following a post-traumatic bleed, treatment was escalated to a doubled Marstacimab dose, with ongoing excellent adherence and no thromboembolic events reported so far.
This case highlights how targeted anti-TFPI therapy, combined with standardised imaging and individualised dose adjustment, may support adherence and help stabilise joint outcomes in haemophilia care.”
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