Jim Hoffman: Does Multiomics Suggest LC PASC Patients Require Multiple Drugs to Correct Biochemical Dysregulation?
Jim Hoffman, Former Technical Advisor at Cygnus Technologies, LLC, shared Paul Watton’s post on LinkedIn, adding:
”So, does multiomics mean that LC PASC patients likely need to be on multiple drugs to correct everything that goes wrong with their biochemistry?
How is this multiomics signature different or similar from that of others who are suffering and diagnosed with non-COVID-related and potentially other comorbid illnesses?
How do we treat patients based on this multiomics information?
I would rather see us stay focused on looking at trying to repair how the viral infection escapes and corrupts the innate complement-facilitated phagocytic clearance system, in vulnerable individuals. The mononuclear phagocytic system is dysfunctional and is responsible for the clearance and metabolism of infectious pathogens and our no longer wanted host cells, which are normally turned over on a daily basis on the order of about 50 billion cells per/day.
Many of these cells become infected and are not cleared self- sufficiently by a process known as ‘efferocytosis’. We must repair efferocytosis, which is dysfunctional and chronically dysregulated in LC patients and many other comorbidities that worsen LC PASC symptoms and vice versa.
For decades, we have known that lupus patients suffer from impaired efferocytosis and reduced clearance of host cells and their debris, which worsens autoantibody profiles and inflammatory flares that subside with disease remission.
A key prognostic indicator of these flares and compromised efferocytosis is that the phagocytic clearance and metabolism of nuclear chromatin released from no longer wanted host cells is also impaired during infectious and non-infectious disease exacerbations.
The pathogenesis of post-acute COVID illness is very similar to other diseases in this regard, particularly to lupus, so why not help advocate for trying a therapy that can treat efferocytosis dysregulation and see if this therapy will help alleviate LC PASC symptoms? You can even put this therapy and others to the test of multiomics to look for improvements post-treatment.
Severe lupus treated by the NucleoCapture device.
‘We found that the presence of viable SARS-CoV-2 in cell corpses dysregulates macrophage anti-inflammatory responses to the efferocytosis of AC, promoting excessive production of inflammatory IL-6 and IL-1β while disrupting the efficient continual clearance of dead cells required for effective tissue repair.’ Cunhu et al 2022
Efferocytosis of SARS-CoV-2-infected dying cells impairs macrophage anti-inflammatory functions and clearance of apoptotic cells.
Cytokine signalling in formation of neutrophil extracellular traps: Implications for health and diseases.”
Paul Watton, Independent Researcher, shared a post on LinkedIn about a recent article by Gisela Gabernet et al., published in the Journal of Clinical Investigation:
”This recently published large scale study by Gabernet et al identifies the ‘disease terrain’ within which Long-COVID develops.
The biological signature associated with poor recovery included persistent inflammatory signalling, disturbed heme-metabolism and anaemia pathways, reduced androgenic steroid metabolites, and a shift toward myeloid-dominant immune responses.
Taken together, these findings suggest that Long Covid may arise from an early-emerging failure of physiological recovery, characterised by a sustained inflammatory and immuno-metabolic state, which is detectable in the circulation.
It is worth noting that it is within this ‘terrain’ that the ‘toxic’ IgG Immune Complex is formed, hence the pathomechanism which results in Endothelial Cell dysfunction (and consequently PEM) suggests that these findings are complementary (not contradictory) and a convergence in these lines of investigation.”
Title 1: Efferocytosis of SARS-CoV-2-infected dying cells impairs macrophage anti-inflammatory functions and clearance of apoptotic cells
Authors: Ana CG Salina, Douglas dos-Santos, Tamara S Rodrigues, Marlon Fortes-Rocha, Edismauro G Freitas-Filho, Daniel L Alzamora-Terrel, Icaro MS Castro, Thais FC Fraga da Silva, Mikhael HF de Lima, Daniele C Nascimento, Camila M Silva, Juliana E Toller-Kawahisa, Amanda Becerra, Samuel Oliveira, Diego B Caetité, Leticia Almeida, Adriene Y Ishimoto, Thais M Lima, Ronaldo B Martins, Flavio Veras, Natália B do Amaral, Marcela C Giannini, Letícia P Bonjorno, Maria IF Lopes, Maira N Benatti, Sabrina S Batah, Rodrigo C Santana, Fernando C Vilar, Maria A Martins, Rodrigo L Assad, Sergio CL de Almeida, Fabiola R de Oliveira, Eurico Arruda Neto, Thiago M Cunha, José C Alves-Filho, Vania LD Bonato, Fernando Q Cunha, Alexandre T Fabro, Helder I Nakaya, Dario S Zamboni, Paulo Louzada-Junior, Rene DR Oliveira, Larissa D Cunha
Read the Full Article on eLife
Title 2: Cytokine signalling in formation of neutrophil extracellular traps: Implications for health and diseases
Authors: Haritha Manoj, Sarah Michael Gomes, Pooja Yedehalli Thimmappa, Prabhakara R. Nagareddy, Colin Jamora, Manjunath B. Joshi
Read the Full Article on Cytokine & Growth Factor Reviews
Title 3: A multiomics recovery factor predicts long COVID in the IMPACC study
Authors: Gisela Gabernet, Jessica Maciuch, Jeremy P Gygi, John F Moore, Annmarie Hoch, Caitlin Syphurs, Tianyi Chu, Naresh Doni Jayavelu, David B Corry, Farrah Kheradmand, Lindsey R Baden, Rafick-Pierre Sekaly, Grace A McComsey, Elias K Haddad, Charles B Cairns, Nadine Rouphael, Ana Fernandez-Sesma, Viviana Simon, Jordan P Metcalf, Nelson I Agudelo Higuita, Catherine L Hough, William B Messer, Mark M Davis, Kari C Nadeau, Bali Pulendran, Monica Kraft, Chris Bime, Elaine F Reed, Joanna Schaenman, David J Erle, Carolyn S Calfee, Mark A Atkinson, Scott C Brakenridge, Esther Melamed, Albert C Shaw, David A Hafler, Alison D Augustine, Patrice M Becker, Al Ozonoff, Steven E Bosinger, Walter Eckalbar, Holden T Maecker, Seunghee Kim-Schulze, Hanno Steen, Florian Krammer, Kerstin Westendorf, Bjoern Peters, Slim Fourati, Matthew C Altman, Ofer Levy, Kinga K Smolen, Ruth R Montgomery, Joann Diray-Arce, Steven H Kleinstein, Leying Guan, Lauren IR Ehrlich
Read the Full Article on Journal of Clinical Investigation
Stay updated with all scientific advances with Hemostasis Today.
-
Mar 31, 2026, 16:05Happy National Doctors’ Day to All Physicians Making a Difference – ASH
-
Mar 31, 2026, 16:03Robert Negrin: Strengthening Collaboration with NCI to Advance Hematology Research
-
Mar 31, 2026, 15:59Seema Dawood: How Blister Cells Reveal Oxidative Damage in G6PD Deficiency
-
Mar 31, 2026, 15:57Ney Carter Borges: HOST-EXAM Shows Clopidogrel Beats Aspirin in Long-Term Monotherapy
-
Mar 31, 2026, 15:57Join the Webinar on Immunoglobulin Access and Stewardship in the UK and Australia – ISBT
-
Mar 31, 2026, 15:55Hind El Azzazi: Successful Defense of My Medical Doctorate on Antiphospholipid Syndrome in Men
-
Mar 31, 2026, 15:54Rucha Patil: Honored to Speak at AIIMS Nagpur ToT Workshop on Advancing Hemophilia A Care
-
Mar 31, 2026, 15:43Deepak Sudheendra: When the Clot Is Gone, but Symptoms Stay
-
Mar 31, 2026, 15:25Chokri Ben Lamine: Pathophysiology, Diagnosis and Management of Hereditary Spherocytosis