Antonio Pineda Guerrero: Elevated Lp(a) Raises VTE Risk But Only in the Right Hormonal Context
Antonio Pineda Guerrero, Research Trainee at INIT-UJI, shared a post on LinkedIn about a recent article by Daniel Ezzat published in European Heart Journal, adding:
“Elevated Lp(a) raises VTE risk but only in the right hormonal context
Prior studies found inconsistent results. The missing variable: Oestrogen.
In the European Heart Journal, data from 373,360 UK Biobank participants (13.6-year follow-up), Lp(a) at or above 125 nmol/L increased VTE risk in premenopausal women (aHR 1.32) and postmenopausal MHT users (aHR 1.48) but not in men or untreated postmenopausal women.
Same molecule. Opposite risk. Depending on hormonal milieu.
Should Lp(a) be part of the conversation before starting hormone therapy?”
Title: Lipoprotein(a) and incident venous thromboembolism in pre- and postmenopausal women, and in men
Authors: Daniel Ezzat, Diana M Lopez, Brian L Claggett, Linke Li, Niekbachsh Mohammadnia, Art Schuermans, Jan Hemeryck, Annie Chang, Samantha Murillo, Michelle L O’Donoghue, Behnood Bikdeli, Zhi Yu, Pradeep Natarajan, Aniruddh P Patel, Maria A Pabon, Michael C Honigberg
Read the Full Article on European Heart Journal
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