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Antonio Pineda Guerrero: Elevated Lp(a) Raises VTE Risk But Only in the Right Hormonal Context
Antonio Pineda Guerrero/LinkedIn
Apr 1, 2026, 17:21

Antonio Pineda Guerrero: Elevated Lp(a) Raises VTE Risk But Only in the Right Hormonal Context

Antonio Pineda Guerrero, Research Trainee at INIT-UJI, shared a post on LinkedIn about a recent article by Daniel Ezzat published in European Heart Journal, adding:

“Elevated Lp(a) raises VTE risk but only in the right hormonal context 

Prior studies found inconsistent results. The missing variable: Oestrogen.

In the European Heart Journal, data from 373,360 UK Biobank participants (13.6-year follow-up), Lp(a) at or above 125 nmol/L increased VTE risk in premenopausal women (aHR 1.32) and postmenopausal MHT users (aHR 1.48) but not in men or untreated postmenopausal women.

Same molecule. Opposite risk. Depending on hormonal milieu.

Should Lp(a) be part of the conversation before starting hormone therapy?”

Title: Lipoprotein(a) and incident venous thromboembolism in pre- and postmenopausal women, and in men

Authors: Daniel Ezzat, Diana M Lopez, Brian L Claggett, Linke Li, Niekbachsh Mohammadnia, Art Schuermans, Jan Hemeryck, Annie Chang, Samantha Murillo, Michelle L O’Donoghue, Behnood Bikdeli, Zhi Yu, Pradeep Natarajan, Aniruddh P Patel, Maria A Pabon, Michael C Honigberg

Read the Full Article on European Heart Journal

Antonio Pineda Guerrero

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Aniruddh P. Patel Annie Chang Antonio Pineda Guerrero Art Schuermans Behnood Bikdeli Blood Brian L Claggett Daniel Ezzat Diana M Lopez European Heart Journal Health Hematology Hemophilia Hemostasis Hemostasis News Hemostasis Today Jan Hemeryck Linke Li Lp(a) Maria A Pabon Medicine Michael C. Honigberg Michelle L O'Donoghue Niekbachsh Mohammadnia Pradeep Natarajan Samantha Murillo stroke thrombosis venous thromboembolism VTE Zhi Yu
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