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Heghine Khachatryan: Marfan vs LDS – Not All Aortopathies Are the Same
Heghine Khachatryan/LinkedIn
Apr 8, 2026, 17:04

Heghine Khachatryan: Marfan vs LDS – Not All Aortopathies Are the Same

Heghine Khachatryan, Editor-in-Chief of Hemostasis Today, Head of Hemophilia and Thrombosis Center at Yeolyan Hematology and Oncology Center, shared RPTH Journal’s post on LinkedIn:

“Marfan vs Loeys – Dietz: Not All Aortopathies Are the Same

Marfan syndrome and Loeys – Dietz syndrome (v) share phenotypic overlap, yet their biological behavior and clinical risk profiles differ fundamentally.

While Marfan syndrome is primarily a structural connective tissue disorder (FBN1-related) with progressive aortic root dilation,

LDS represents a TGF-β – driven vasculopathy characterized by:

  • Aggressive and early-onset aneurysms
  • Widespread arterial involvement (beyond the aorta)
  • Marked vascular tortuosity
  • Encreased risk of dissection at smaller diameters

Importantly, LDS should be approached not merely as an aortopathy, but as a systemic vascular fragility condition, with implications for:

  • Earlier surgical thresholds
  • Meticulous perioperative planning
  • Individualized risk assessment

Normal coagulation tests do not exclude bleeding risk in LDS.

Clinical Insight

  • Marfan – structural aortopathy
  • Loeys – Dietz – aggressive systemic vasculopathy

Recognizing this distinction is not academic – it is life – saving.”

Heghine Khachatryan

More posts featuring Heghine Khachatryan on Hemostasis Today.

Health Heghine Khachatryan Hematology Hemostasis Hemostasis News Hemostasis Today LDS Loeys - Dietz Marfan Medicine
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