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Phil Spinella: What Dose of TXA for Children With Severe Traumatic Bleeding Should You Use?
Phil Spinella/surgery.pitt.edu
Apr 14, 2026, 17:11

Phil Spinella: What Dose of TXA for Children With Severe Traumatic Bleeding Should You Use?

Phil Spinella, Co Director, Trauma and Transfusion Medicine Research Center at the University of Pittsburgh, shared a post on LinkedIn about a recent article he and his colleagues co-authored, adding:

“What dose of TXA for children with severe traumatic bleeding should you use?

See the below dose simulation study for some answers.

By the way it is alright to push IV based on these simulations. The MATIC-2 trial will give us direct PK and PD data for EMS systems and hospitals willing to participate in the trial.”

Title: Tranexamic acid dosing in pediatric trauma: Dose simulation based on population pharmacokinetic modeling in adult trauma patients

Authors: Gideon Stitt, Kevin Downes, Athena Zuppa, Christine Leeper, Kevin Watt, Philip Spinella

Read the Full Article on Transfusion

Phil Spinella: What Dose of TXA for Children With Severe Traumatic Bleeding Should You Use?

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Athena Zuppa bleeding Blood Christine Leeper EMS Gideon Stitt Health Hematology Hemophilia Hemostasis Hemostasis News Hemostasis Today Kevin Downes Kevin Watt MATIC-2 Medicine Phil Spinella Philip Spinella TXA
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