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Ashkan Shoamanesh: Factor XI Inhibition and the Future of Antithrombotic Therapy
Ashkan Shoamanesh/LinkedIn
Apr 21, 2026, 15:32

Ashkan Shoamanesh: Factor XI Inhibition and the Future of Antithrombotic Therapy

Ashkan Shoamanesh, Associate Professor of Medicine (Neurology), Marta and Owen Boris Chair in Stroke Research and Care at McMaster University, shared on LinkedIn about a recent article he and his colleagues co-authored, published in NEJM Group, adding:

”The OCEANIC-STROKE results published in NEJM Group last week advance the promise of factor XI/XIa inhibition as a new paradigm in antithrombotic therapy.

In discussion with HCP Live Cardiology, we explore what these findings mean for patients with non-cardioembolic stroke or high-risk TIA – particularly asundexian’s ability to reduce ischemic stroke risk without increasing bleeding.

Beyond stroke, FXI inhibition may have broader implications across cardiovascular disease, where the balance between thrombosis and bleeding has long constrained progress.

Very grateful to contribute to this evolving chapter in secondary prevention alongside my colleagues.”

Proceed to the interview.

Title: Asundexian for Secondary Stroke Prevention

Authors: Mukul Sharma, Qiang Dong, Teruyuki Hirano, Scott Kasner, Jeffrey Saver, Jaime Masjuan, Andrew Demchuk, Charlotte Cordonnier, Daniel Bereczki, Georgios Tsivgoulis, Roland Veltkamp, Ivan Staikov, Hee-Joon Bae, Bruce Campbell, Andrea Zini, I-Hui Lee, Martin Kovar, Robert Mikulik, Robin Lemmens, José Ferro, Thompson Robinson, Hanne Christensen, Serefnur Ozturk, Ronen Leker, Peter Turcani, Agnieszka Slowik, Pablo Amaya, Fan Kee Hoo, Gian Marco De Marchis, Michael Knoflach, P.N. Sylaja, Jukka Putaala, Jonathan Coutinho, H. Bart van der Worp, Evija Miglane, Vaidas Matijošaitis, Arne Lindgren, Gisele Sampaio Silva, Else Charlotte Sandset, Saule Turuspekova, Pierre Amarenco, Kevin Sheth, Eric Smith, John Eikelboom, Raed Joundi, Karleen Schulze, Lizhen Xu, Laura Heenan, Pablo Colorado, Lars Keller, Eva Muehlhofer, Christoph Neumann, Hardi Mundl, Ashkan Shoamanesh for the OCEANIC-STROKE Investigators

Ashkan Shoamanesh: Factor XI Inhibition and the Future of Antithrombotic Therapy

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Agnieszka Slowik Andrea Zini Andrew Demchuk antithrombotic therapy Arne Lindgren Ashkan Shoamanesh asundexian Bruce Campbell Charlotte Cordonnier Christoph Neumann Daniel Bereczki Else Charlotte Sandset Eric Smith Eva Muehlhofer Evija Miglane Fan Kee Hoo Georgios Tsivgoulis Gian Marco De Marchis Gisele Sampaio Silva H. Bart van der Worp Hanne Christensen Hardi Mundl HCP Live Cardiology Health Hee-Joon Bae Hematology Hemostasis Hemostasis News Hemostasis Today I-Hui Lee Ivan Staikov Jaime Masjuan Jeffrey Saver John Eikelboom Jonathan Coutinho José Ferro Jukka Putaala Karleen Schulze Kevin Sheth Lars Keller Laura Heenan Lizhen Xu Martin Kovar Medicine Michael Knoflach Mukul Sharma NEJM Group non-cardioembolic stroke OCEANIC-STROKE P.N. Sylaja Pablo Amaya Pablo Colorado Peter Turcani Pierre Amarenco Qiang Dong Raed Joundi Robert Mikulik Robin Lemmens Roland Veltkamp Ronen Leker Saule Turuspekova Scott Kasner secondary stroke Serefnur Ozturk Teruyuki Hirano Thompson Robinson thrombosis TIA Vaidas Matijošaitis
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