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Patent Foramen Ovale and Stroke: David Kent and Andy Wang Break It Down
University of California/Tufts CTSI
Aug 8, 2025, 17:15

Patent Foramen Ovale and Stroke: David Kent and Andy Wang Break It Down

Vasculearn Network shared an insightful post on LinkedIn:

”ICYMI: PFO and Stroke – Who Benefits from Closure?

About 1 in 4 adults has a PFO, but not everyone needs it closed. A new July 2025 JAMA review reframes PFO closure as targeted, not routine, therapy for select stroke patients.

Key tools guiding treatment:

  • RoPE score: Predicts if stroke is PFO-related
  • PASCAL system: Adds anatomy to assess stroke causality

Best candidates?

  • Age ≤60
  • Cryptogenic stroke
  • High PASCAL score
  • No vascular risk factors

In these patients, closure cuts stroke recurrence risk by up to 90% at 2 years.

Everyone else? Medical therapy still leads with individualized decisions on antiplatelet vs. anticoagulant”

Find the full update on the community.

Read the full article here.

Article: Patent Foramen Ovale and Stroke. A Review

Authors: David M. Kent, Andy Y. Wang

Patent Foramen Ovale and Stroke: David Kent and Andy Wang Break It Down

Stay informed on all the scientific advances in hematology with Hemostasis Today.

Andy Y. Wang anticoagulants Antiplatelets Cryptogenic Stroke David M. Kent Health Hematology Hemostasis Today JAMA Medicine PASCAL system Patent Foramen Ovale PFO RoPE score stroke
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