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Iron Deficiency in Polycythemia Vera: William Aird Reveals JAK2-Driven Erythropoiesis as The Key Cause
William Aird/X
Aug 16, 2025, 14:00

Iron Deficiency in Polycythemia Vera: William Aird Reveals JAK2-Driven Erythropoiesis as The Key Cause

William Aird, Professor of Medicine at Harvard Medical School, shared an insightful thread on X:

”IRON DEFICIENCY (ID) IN POLYCYTEMIA VERA (PV)

  • Despite what we are taught, there is simply no evidence that iron deficiency, a common finding at presentation of PV, is caused by occult or overt bleeding.
  • Rather, ID is much more likely to be explained by high erythroid iron demand from JAK2-driven erythropoiesis, which rapidly consumes available iron stores and unmasks or worsens deficiency.
  • The iron cost of building a larger RBC mass (e.g., Hct 45→60 ≈ 740 mg) comes from stores. If stores are small, they can be drained in weeks, explaining iron deficiency at presentation without any bleeding.”

Find more featured in Hemostasis Today.

Erythropoiesis Harvard Medical School Health Hematology Hemostasis Today Iron-Deficiency JAK2 Medicine polycythemia vera PV William Aird
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