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Andreas Calatzis: What is the Rationale for Collagen-Induced Platelet Aggregation Testing?
Andreas Calatzis/LinkedIn
Jul 9, 2026, 12:08

Andreas Calatzis: What is the Rationale for Collagen-Induced Platelet Aggregation Testing?

Andreas Calatzis, Managing Director of Eonis GmbH and Dynabyte GmbH, shared a post on LinkedIn:

“What is the rationale for collagen-induced platelet aggregation testing?

When we developed the Multiplate analyzer more than 20 years ago, collagen was one of the available agonists alongside ADP, arachidonic acid and TRAP-6.

Although the collagen reagent was used by many laboratories, I never fully understood why it was used.

With the IVDR, manufacturers are expected to define a clear intended purpose and demonstrate the analytical and clinical performance of the device.

So I’d be interested in hearing the community’s views:

  1. Does collagen-induced platelet aggregation still have a meaningful role alongside ADP, arachidonic acid and TRAP-6?
  2. If so, what could the intended use actually be?

The answer to the second question will immediately lead to the next one:

Can this intended use be demonstrated in analytical and clinical performance studies?

I’d be very interested to hear how clinicians, laboratory physicians and researchers see the role of collagen-induced platelet aggregation today.”

Find more posts featuring Andreas Calatzis on Hemostasis Today.

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