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Hakan Ismail Sari: Treatment of Thrombotic Thrombocytopenic Purpura
Hakan Ismail Sari/Facebook
Aug 17, 2026, 20:14

Hakan Ismail Sari: Treatment of Thrombotic Thrombocytopenic Purpura

Hakan Ismail Sari, Internal Medicine and Hematology Specialist at Memorial Ataşehir Hospital, shared a post on X:

“Treatment of Thrombotic Thrombocytopenic Purpura (TTP) 

4 main methods stand out in the treatment of TTP:

  1. Therapeutic Plasma Exchange: The patient’s plasma is replaced using specialized apheresis devices. In immune TTP, harmful antibodies are removed, and the healthy ADAMTS13 enzyme is restored to the patient (ADAMTS13 activity must be checked before the procedure).
  2. Steroid (cortisone) Treatment: It is usually started right at the beginning along with plasma exchange or can be added later in unresponsive cases.
  3. Caplacizumab Treatment: A targeted therapy that prevents the binding of von Willebrand factor to platelets. It is mostly used alongside plasma exchange and must be continued for 30 more days after the exchange ends.
  4. Rituximab Treatment: A monoclonal antibody that reduces B cells, thereby lowering harmful antibody production. This increases ADAMTS13 levels, raises platelets, and helps the disease recover.

NOTE: In congenital TTP, plasma and the missing ADAMTS13 enzyme are administered at regular intervals.”

Proceed to the video attached to the post.

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ADAMTS13 apheresis B Cells Blood Caplacizumab cortisone Hakan Ismail Sari Health Hematology Hemostasis Hemostasis News Hemostasis Today Medicine 𝗣𝗹𝗮𝘀𝗺𝗮 platelets Steroid Treatment Therapeutic Plasma Exchange thrombosis Thrombotic thrombocytopenic purpura TTP Von Willebrand Factor VWF
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