Ahmet Davut Aksu: A Multi-Objective Approach to Enhance Fibrinolysis, Selectivity, and Inhibition Resistance
Ahmet Davut Aksu, Researcher at University of Masarykova, shared a post on LinkedIn about a recent article he and his colleagues co-authored, published in ACS Catalysis, adding:
“I am happy to share our new publication, which presents a multi-objective engineering strategy designed to optimize fibrinolytic efficacy, fibrin selectivity, and inhibition resistance within a single workflow.
The lead variant produced under this approach, Brnoteplase, demonstrated improved fibrin selectivity, resistance to inhibiton, and elevated clot penetration, together extending the effective catalytic lifetime and enabling bolus administration.”
Title: Multiobjective Engineering of Fibrin-Selective Thrombolytic Proteases with Enhanced Biocatalytic Efficiency and Inhibition Resistance
Authors: Martin Toul, Veronika Slonková, Jan Mičan, Sandra Thalerova, Michaela Pešková, Patrícia Kittová, Peter Scheer, Jana Hlozkova, Eliska Brhelova, Ahmet Davut Aksu, Jan Biskupič, Michaela Kuchynka, Jaroslav Ondruš, Petr Kasparek, Tereza Batkova, Martin Marek, Jan Víteček, Lukas Kubala, Robert Mikulik, Jiří Damborský, David Bednar, Zbynek Prokop
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