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Laurent Arnaud: Rare SLE Manifestations Demand More Than Rare Attention – Insights from The Lancet Rheumatology
Laurent Arnaud/LinkedIn
Aug 29, 2026, 15:06

Laurent Arnaud: Rare SLE Manifestations Demand More Than Rare Attention – Insights from The Lancet Rheumatology

Laurent Arnaud, Executive committee member at ERN ReCONNET, shared a post on LinkedIn about a recent article he and his colleagues co-authored, published in The Lancet Rheumatology, adding:

“Rare manifestations of Lupus SLE need more than rare attention

We have just published PART 2 in the The Lancet Rheumatology

Free access for 50 days.

A international consensus effort brings together 77 SLE experts from three leading expert groups to address 22 additional rare manifestations of SLE – areas where clinical evidence is often limited and therapeutic decisions can be particularly challenging.

The manifestations covered are remarkably diverse, including:

  • Diffuse pulmonary haemorrhage
  • Bullous, chilblain, tumidus and other rare cutaneous lupus manifestations
  • Lupus podocytopathy and interstitial nephritis
  • Chorea, small fibre neuropathy, catatonia and intracranial hypertension
  • Protein-losing enteropathy, lupus hepatitis and intestinal pseudo-obstruction
  • Myositis and Jaccoud’s arthropathy
  • Uveitis
  • Anti-C1 esterase inhibitor antibody–associated angioedema

And other rare manifestations, including interstitial cystitis and lupus mastitis

The key message: when high-quality evidence is scarce, expert consensus can provide an important clinical framework – helping physicians navigate complex presentations that may otherwise fall outside conventional guideline pathways.

It is a reminder that SLE is extraordinarily heterogeneous – and our approach to treatment needs to reflect that.

Consensus strategies like these can help bridge the gap between ‘there is limited evidence’ and ‘we still need to make the best decision for this patient.'”

Title: ERN ReCONNET–SLICC–SLEuro consensus on the therapeutic management of rare systemic lupus erythematosus manifestations (part 2)

Authors: Laurent Arnaud, Odirlei A Monticielo, Matteo Piga, Nathalie Costedoat-Chalumeau, Zahi Touma, Guillermo Ruiz-Irastorza, Sang-Cheol Bae, Sasha Bernatsky, Eloisa Bonfa, Francesca Bottazzi, Ricard Cervera, Gamal Chehab, Ann E Clarke, Maria Dall’era, Alí Duarte-Garcia, Gerard Espinosa, Paul R Fortin, Micaela Fredi, José A Gómez-Puerta, Shinji Izuka, Andreas Jönsen, Nikita Khmelinskii, Alexandra Legge, Sandra Meisalu, Luca Moroni, Giovanni Orsolini, Ivan Padjen, Michelle Petri, Guillermo Pons-Estel, Giuseppe A Ramirez, Rosalind Ramsey-Goldman, Savino Sciascia, Angela Tincani, Massimo Triggiani, Manuel F Ugarte-Gil, Evelyne Vinet, Edward M Vital, Marta Mosca, Chiara Tani, Cristiano Alessandri, Cynthia Aranow, Anca Askanase, George Bertsias, Riccardo Bixio, Ashira Blazer, Francesca Bottazzi, Hermine Brunner, Inita Bulina, Irene E.M. Bultink, Francois Chasset, Maria Sole Chimenti, Jacqueline S. Dekkers, Elena Elefante, Raquel Faria, Francesca Faustini, Mariele Gatto, Philipp Gauckler, Sara Guerreiro Castro, Iva Gunnarsson, Ihsane Hmamouchi, Murat Inanç, Kenneth Kalunian, Sylvia Kamphuis, Anne-Sophie Korganow, Sam Lim, Maarten Limper, Carla Macieira, Anselm Mak, Susan Manzi, Marzena Olesinska, George Omondi Oyoo, Cristina Pamfil, José M. Pego-Reigosa, Anisur Rahman, Simona Rednic, Jorge Sanchez-Guerrero, Davide Schilirò, Raphaele Seror, Elisabet Svenungsson, Farah Tamirou, Dana Tegzová, Maria Tektonidou, Simona Truglia, Michel Tsang-A-Sjoe, Ronald van Vollenhoven, Carlos Vasconcelos, Jakub Závada, Julija Zepa

Laurent Arnaud

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Alexandra Legge Alí Duarte-García Anca Askanase Andreas Jönsen Angela Tincani Anisur Rahman Ann E Clarke Anne-Sophie Korganow Anselm Mak Ashira Blazer Carla Macieira Carlos Vasconcelos Chiara Tani Cristiano Alessandri Cristina Pamfil Cynthia Aranow Dana Tegzová Davide Schilirò Edward M Vital Elena Elefante Elisabet Svenungsson Eloisa Bonfa Evelyne Vinet Farah Tamirou Francesca Bottazzi Francesca Faustini François Chasset Gamal Chehab George Bertsias George Omondi Oyoo Gerard Espinosa Giovanni Orsolini Giuseppe A Ramirez Guillermo Pons-Estel Guillermo Ruiz-Irastorza Health Hematology Hemostasis Hemostasis News Hemostasis Today Hermine Brunner Ihsane Hmamouchi Inita Bulina Irene E.M. Bultink Iva Gunnarsson Ivan Padjen Jacqueline S. Dekkers Jakub Závada Jorge Sanchez-Guerrero José A Gómez-Puerta José M. Pego-Reigosa Julija Zepa Kenneth Kalunian Laurent Arnaud Luca Moroni Maarten Limper Manuel F Ugarte-Gil Maria Dall’era Maria Sole Chimenti Maria Tektonidou Mariele Gatto Marta Mosca Marzena Olesinska Massimo Triggiani Matteo Piga Medicine Micaela Fredi Michel Tsang-A-Sjoe Michelle Petri Murat Inanç Nathalie Costedoat-Chalumeau Nikita Khmelinskii Odirlei A Monticielo Paul R Fortin Philipp Gauckler Raphaèle Seror Raquel Faria Ricard Cervera Riccardo Bixio Ronald van Vollenhoven Rosalind Ramsey-Goldman Sam Lim Sandra Meisalu Sang-Cheol Bae Sara Guerreiro Castro Sasha Bernatsky Savino Sciascia Shinji Izuka Simona Rednic Simona Truglia Susan Manzi Sylvia Kamphuis The Lancet Rheumatology Zahi Touma
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