Wolfgang Miesbach: Haemorrhage Risk May Be Transferred From Donor to Recipient
Wolfgang Miesbach, Head of the Hemostasis and Hemophilia Center at Department of Medicine II, University Hospital Frankfurt, shared a post on LinkedIn about a recent article by Gargi Banerjee et al., published in The Lancet, adding:
”Haemorrhage risk appears transferrable from blood donor to recipient.
A Lancet Viewpoint from a workshop convened by the MRC Prion Unit at UCL in 2024, with clinicians, epidemiologists and transfusion specialists:
Amyloid β (Aβ) propagates by templated seeding, the mechanism of the prion protein. It circulates in plasma, comes from platelets, binds to red cells. In rodents, blood from amyloid-bearing animals seeds cerebral amyloidosis in the recipient.
Denmark and Sweden, 1.27 million donors and 1.09 million recipients: recipients of red cells from donors who later had repeated intracerebral haemorrhages, the pattern typical of cerebral amyloid angiopathy, had a higher haemorrhage risk themselves. Registry data only, no imaging, no histology.
Open questions: are plasma-derived products, including factor concentrates, affected?
Not yet examined. Latency unknown. No assay measures Aβ seeds in plasma.
p-tau217 could screen donors, but the meaning of a positive result in a healthy donor is undefined.”
Title: Risk of transmission of amyloid β pathology via transfused blood products
Authors: Gargi Banerjee, Gustaf Edgren, Jingcheng Zhao, Neil M Ferguson, Heli Harvala, James Hope, Graham S Jackson, Philip J Lowry, Simon Mead, Silvia A Purro, Jonathan M Schott, Marc L Turner, David J Werring, Henrik Zetterberg, John Collinge
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