Jean Nakhle: Uncovering How Excess Cysteine Drives Cell Death
Jean Nakhle, Senior Editor at Nature Metabolism, shared a post on LinkedIn about recent articles, published in Nature Metabolism, adding:
“Out now in Nature Metabolism:
Why is excess cysteine toxic?
Kivanç Birsoy and colleagues show that cysteine overload triggers a mitochondrial iron-dependent cell death that is mechanistically distinct from ferroptosis and disulfidptosis.
The accompanying News and Views led by Jessalyn Ubellacker.
These findings nicely complement the study by Lucas Sullivan, showing that excess cysteine forms toxic conjugates that impair proliferation.”
Title 1: Cysteine excess triggers a mitochondrial iron-dependent cell death
Authors: Toshitaka Nakamura, Ayaka Inoki, Nupur K. Das, Brandon Chen, Artem Khan, Yuyang Liu, Beste Uygur, Frederick S. Yen, Gokhan Unlu, Yatrik M. Shah, Kıvanç Birsoy
Title 2: The high price of ‘free’ cysteine
Authors: Megan Cheah, Jessalyn M. Ubellacker
Title 3: Excess cysteine drives conjugate formation and impairs proliferation of NRF2-activated cancer cells
Authors: Jennifer A. Brain, Anna-Lena B. G. Vigil, Kristian Davidsen, Ayaha Itokawa, Abby C. Jurasin, Hannah J. Kerbyson, Maximilian Kobiesa, Madeleine L. Hart, Sang Jun Yoon, Peter Bellotti, Juan Pablo Maianti, Gina M. DeNicola, Lucas B. Sullivan
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