Lisa Laun: Spleen Clears Activated Platelets to Limit Thrombosis and Inflammation
Lisa Laun, Doctoral Candidate at Ludwig-Maximilians-University of München, shared a post on LinkedIn:
“Where do activated platelets go?
Beyond happy to share our answer, published in Science Magazine!
We found that the spleen selectively filters out platelets activated by thrombotic or inflammatory stimuli, thereby limiting thrombosis, inflammation, and venous thromboembolism.
When platelets enter the splenic red pulp, they encounter activating signals from the extracellular matrix.
Under physiological conditions, this is counterbalanced by inhibitory G6b-signaling.
However, in already activated platelets, this balance is tipped, inducing adhesion and clearance from systemic circulation.
Deeply grateful to the brilliant Leo Nicolai, Steffen Massberg, Felix Zhang and Alexander Leunig, and all our coauthors and collaborators.”
Title: Splenic regulation of systemic platelet activation state
Authors: Lisa Laun, Alexander Leunig, Felix Zhang, Sezer Akgöl, Dario Rossaro, Matthias P. Fabritius, Afra Anjum, Lennart Kreutz, Nathalie Mackert, Gabriel H.M. Araujo, Shaan Mahameed, Craig Balmforth, Marie-Louise Hoffknecht, Magdalena Mader, Konstantin Hoffmann, Justus Reittinger, Johanna Knechtel, Nellie M. Kwabla, Maité Mulkers, Michael Schmid, Jean Solarz, Hannah Niederdorfer, Raphael Escaig, Robin Dewender, Heiko Schulz, Frederick Klauschen, Konstantin Stark, Florian Gaertner, David E. Newby, Bernhard Nieswandt, Filip K. Swirski, Zoltan Nagy, Alexandra Mazharian, Rainer Kaiser, Yotis A. Senis, Steffen Massberg, Leo Nicolai
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