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Low-Dose DOACs Reduce VTE Risk in Transplant-Ineligible Multiple Myeloma: Insights from the BENEFIT Trial
Journal of Thrombosis and Haemostasis (JTH)/LinkedIn
Sep 1, 2025, 15:31

Low-Dose DOACs Reduce VTE Risk in Transplant-Ineligible Multiple Myeloma: Insights from the BENEFIT Trial

Journal of Thrombosis and Haemostasis (JTH) has shared a post on LinkedIn:

“Thromboembolism in transplant-ineligible multiple myeloma patients on triplet/quadruplet therapy: a post hoc analysis of the BENEFIT trial

In this phase 3 trial of 257 patients with transplant-ineligible newly diagnosed multiple myeloma, the 6-month cumulative incidence of VTE was 4.8%. Among prophylaxis strategies, low-dose DOACs significantly reduced VTE risk compared to heparin or aspirin. Proteinuria ≥0.44 g/L and monoclonal protein ≥22 g/L emerged as strong independent risk factors for VTE. Findings highlight DOACs as a potentially superior prophylaxis option in this high-risk population.”

Title: Thromboembolism in transplant-ineligible multiple myeloma patients on triplet/quadruplet therapy: a post hoc analysis of BENEFIT trial

Authors: Emilie Chalayer, Corinne Frere, Elisabeth Daguenet, Thomas Lecompte, Bernard Tardy, Ilhame Bounouara, Manon Sapet, Arthur Bobin, Stephanie Harel, Olivier Decaux, Karim Belhadj, Cyrille Touzeau, Margaret Macro, Mohamad Mohty, Philippe Moreau, Jill Corre, Hervé Avet–Loiseau, Lionel Karlin, Thierry Facon, Aurore Perrot, Cyrille Hulin, Salomon Manier, Laurent Frenzel, Xavier Leleu

Multiple Myeloma

Read the full paper here.

Find similar posts on Hemostasis Today.

Anticoagulation Arthur Bobin Aurore Perrot BENEFIT Bernard Tardy Corinne Frere Cyrille Hulin Cyrille Touzeau Elisabeth Daguenet Emilie Chalayer Hematology Hemostasis Hemostasis Today Hervé Avet–Loiseau Ilhame Bounouara Jill Corre Karim Belhadj Laurent Frenzel Lionel Karlin Low-Dose DOACs Manon Sapet Margaret Macro Mohamad Mohty multiple myeloma Olivier Decaux Philippe Moreau Salomon Manier Stephanie Harel Thierry Facon Thomas Lecompte thrombosis Transplant-Ineligible VTE Xavier Leleu
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