Francesca Palandri/LinkedIn
Sep 24, 2026, 12:34
Francesca Palandri: Is There Still a Place for Splenectomy in ITP in the Modern Era?
Francesca Palandri, Hematologist at IRCCS Sant’Orsola Polyclinic – Bologna University Hospital, shared a post on LinkedIn:
“Is there still a place for splenectomy in ITP in the modern era?
With TPO-RAs and rituximab available, splenectomy is often seen as a thing of the past.
In the GIMEMA ITP1324 study, we analyzed a multicentre cohort of 97 adults with ITP who had a splenectomy between 2010 and 2022.
Our data were presented at SIE – Italian Society of Hematology and suggest the answer is yes:
- Still effective: 59–69% overall response in the first 6 months (CR up to 65%), despite use after >4 lines of medical therapy.
- A safe procedure with modern prophylaxis: 94% of patients were vaccinated, prior rituximab and the surgical approach did not change response or complications.
- Choosing patients matters: patients ≥60 years responded less often and needed further treatment almost twice as often (62% vs 37%).
Splenectomy is still a valid option in today’s ITP treatment pathway.”
Other posts featuring Francesca Palandri on Hemostasis Today.
-
Nov 10, 2026, 16:28Can the VWF to ADAMTS-13 Ratio Predict Mortality in Sepsis-Induced Coagulopathy? – RPTH Journal
-
Nov 10, 2026, 16:28Ruth Willems: PhD Defence at Maastricht University on Thrombosis and Bleeding in HPB Disease
-
Nov 10, 2026, 16:09Edward Lee Carter: Factor XIa Inhibition Enters Clinical Practice
-
Nov 10, 2026, 16:08Edward C.C. Wong: Deriving Ferritin Cutoffs for Iron Deficiency Using RBC Parameters
-
Nov 10, 2026, 16:07Milad Abdalla: Decoding Hemoglobin Electrophoresis – A Practical Diagnostic Reference
-
Nov 10, 2026, 15:13Wolfgang Miesbach: Nonviral Gene Therapy for Haemophilia A Using Lipid Nanoparticles
-
Nov 10, 2026, 15:06Dahra Teles: First Speaking Experience at HEMO 2026 on First-Line Multiple Myeloma Treatment
-
Nov 10, 2026, 14:55Yazan Abou-Ismail: First FDA-Approved Factor XIa Inhibitor for Stroke Prevention
-
Nov 10, 2026, 14:49Ifeanyichukwu Ifechidere: The Role of Coagulation in Anaesthesia and Surgery