Mary Cushman: Antiphospholipid Antibodies and Their Association with Ischemic Stroke
Mary Cushman, President Elect at International Society on Thrombosis and Haemostasis (ISTH), shared a post on LinkedIn about a recent article she and her colleagues co-authored, published in Stroke, adding:
“Antiphospholipid antibodies and stroke
Lots of interesting findings in this new study I helped out with. Anything surprising to you?
- 52 studies (40 case-control, 12 cohort).
- Prevalence of aPL seropositivity in 9438 patients with ischemic stroke: 19.1% (95% CI, 15.4%-23.0%). That’s high!
- aPL seropositivity associated with higher odds of first ischemic stroke (43 studies, 19 097 patients; OR, 2.93 (95% CI, 2.31-3.73)
- Strongest associations for lupus anticoagulant: OR, 6.69 (95% CI, 2.94-15.2).
What do we do next?
- Test all ischemic stroke patients and confirm if they have APS
- Consider other treatments for these patients? Anticoagulation, immune modulation?
- If we test broadly, should all APS patients with stroke be anticoagulated? With DOAC or warfarin?
Thankful to Behnood Bikdeli for his leadership on this.”
Title: Prevalence and Clinical Relevance of Antiphospholipid Antibodies in Ischemic Stroke: A Systematic Review and Meta-Analysis
Authors: Nathan Watson, Syed Bukhari, Sina Rashedi, Mariana Pfeferman, Francisco Ujueta, Bassil Bacare, Brittany Weber, Mehrdad Zarghami, Yogendra Kanthi, Eric Secemsky, Jean Connors, Geoffrey Barnes, Sacha Uljon, Samuel Goldhaber, Jeffrey Weitz, Karen Costenbader, Harlan Krumholz, Gregory Piazza, Mary Cushman, Christopher Anderson, Mitchell Elkind, Behnood Bikdeli
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