Tamer El-Sayed: Could Anaemia Be an Overlooked Factor in Patients with Intermittent Claudication?
Tamer El-Sayed, NIHR Clinical Lecturer in Vascular Surgery at Newcastle University, Vascular Surgery Registrar at The Newcastle Upon Tyne Hospitals NHS Foundation Trust, shared a post on LinkedIn about a recent article he and his colleagues co-authored, published in Annals of Vascular Surgery, adding:
“Could anaemia be an overlooked factor in patients with intermittent claudication?
Delighted to share our latest publication in Annals of Vascular Surgery:
‘Anemia Prevalence, Characterization, and Clinical Impact in Intermittent Claudication.’
In this study, we evaluated 403 patients with intermittent claudication attending the Newcastle Vascular Centre, examining the prevalence of anaemia, current investigation and treatment practices, and clinical outcomes over 24 months.
Our key findings:
- 17.6% of patients with claudication had anaemia.
- 77.8% of anaemic patients received no treatment, and only one-third underwent iron studies.
- Anaemia was independently associated with an almost threefold higher hazard of major adverse cardiovascular events and a 4.6-fold higher hazard of all-cause mortality.
- Patients receiving iron therapy showed a trend towards greater improvement in claudication symptoms, although this did not reach statistical significance.
These findings highlight an important and potentially modifiable gap in the management of intermittent claudication.
While current treatment focuses largely on cardiovascular risk reduction, exercise therapy and revascularisation, the contribution of anaemia and iron deficiency to walking impairment remains poorly understood.
The next question is whether identifying and treating anaemia can improve walking performance, symptoms and quality of life in these patients.
Watch this space – more exciting research to come!
Many thanks to Jae Seon Hong, Grace Loy, Ashwin Sivaharan, Sarah Sillito and Sandip Nandhra for their outstanding contributions to this work.”
Title: Anemia Prevalence, Characterization, and Clinical Impact in Intermittent Claudication
Authors: Jae Seon Hong, Grace Loy, Ashwin Sivaharan, Sarah Sillito, Sandip Nandhra, Tamer El-Sayed
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