Dragoș Claudiu Popescu: Corticosteroid Exposure and Thrombotic Risk in ITP
Dragoș Claudiu Popescu, Hematology MD at FocusMed, shared a post on LinkedIn about a recent article he and his colleagues co-authored, published in Hemato, adding:
“Our systematic review and meta-analysis, ‘Corticosteroids and Thrombotic Risk in Immune Thrombocytopenia’, is now published open access in Hemato MDPI.
The question came up during a discussion at the EHA 2026 Congress, raised by Jecko Thachil :
Do corticosteroids add to the thrombotic risk already present in ITP?
Many of us ask this in daily practice, but the evidence had not been systematically brought together.
We set out to identify all the evidence currently available. Twelve studies (18,059 participants) met our criteria. The data are scarce and of low certainty, and they rest largely on one nationwide cohort. They do, however, point in one direction.
Current corticosteroid exposure was associated with an approximately 3.5-fold higher hazard of venous thrombosis, with no consistent association with arterial thrombosis.
There is clearly room for more work.
Useful next steps would be:
- time-varying exposure analyses in other large databases
- separate reporting of venous and arterial events
- dose and duration data
- systematic reporting of thrombotic events in ITP trials
Many thanks to my co-authors for their work on this project.”
Title: Corticosteroids and Thrombotic Risk in Immune Thrombocytopenia: A Systematic Review and Meta-Analysis
Authors: Dragoș-Claudiu Popescu, Mihnea-Alexandru Găman, Raluca Truican, Cătălina Olărașu, Daniela Diaconescu, Cristina-Maria Ciufu, Ruxandra Maria Irimia, Horia Bumbea, Delia Soare
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