Abdul Muqtadir Abbasi/LinkedIn
Sep 29, 2026, 10:36
Abdul Muqtadir Abbasi: 5 Questions to Ask When the CBC Is Abnormal
Abdul Muqtadir Abbasi, Assistant Consultant at King Faisal Specialist Hospital and Research Center, shared a post on LinkedIn:
“When you see an abnormal CBC, don’t stop at the flagged value.
Ask 5 actionable questions:
1. Is it isolated or are multiple cell lines affected?
- This immediately narrows the differential.
2.What does the MCV tell me?
- Microcytic, normocytic, or macrocytic anemia points you in different directions.
3.What does the peripheral smear show?
- Blasts, schistocytes, spherocytes, target cells, rouleaux… morphology can change the entire workup.
4.Is this new or chronic?
- Compare with previous CBCs before launching an extensive investigation.
5.Does the clinical picture fit?
- Symptoms, medications, infection, bleeding, organ dysfunction and recent treatment may explain the abnormality.
The CBC gives you the clue. Your job is to connect the clues.”
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