Ahmed Kotb/X
Jul 26, 2026, 13:32
Ahmed Kotb: A Practical Guide to Von Willebrand Disease
Ahmed Kotb, Hematologist and Bone Marrow Transplant Physician at King Faisal Specialist Hospital International Holding Company (KFSHI), shared a post on X:
”Von Willebrand Disease (VWD)
Type 1: Partial decrease in von Willebrand factor (VWF) – usually responds to desmopressin (DDAVP).
Type 2: Qualitative defect in VWF.
- Type 2A: Decreased high-molecular-weight (HMW) multimers.
- Type 2B: Increased binding to platelet glycoprotein Ib (GPIb), resulting in thrombocytopenia; avoid DDAVP.
- Type 2M: Decreased platelet adhesion.
- Type 2N: Decreased binding to factor VIII (FVIII).
Type 3: Complete absence of VWF, causing severe disease; treat with VWF/FVIII concentrate.
Laboratory findings: Decreased VWF antigen, decreased VWF activity, and factor VIII may be decreased.”
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